Hormonal alteration in obese adolescents with eating disorder: Effects of multidisciplinary therapy

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dc.contributor.authorCarnier, June [UNIFESP]
dc.contributor.authorLofrano, Mara Cristina [UNIFESP]
dc.contributor.authorPrado, Wagner Luiz do [UNIFESP]
dc.contributor.authorCaranti, Danielle Arisa [UNIFESP]
dc.contributor.authorPiano, Aline de [UNIFESP]
dc.contributor.authorTock, Lian [UNIFESP]
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorDâmaso, Ana Raimunda [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:49:27Z
dc.date.available2016-01-24T13:49:27Z
dc.date.issued2008-01-01
dc.description.abstractBackground/Aims: Ghrelin and leptin play important roles in the physiopathology of eating disorders, starting generally in infancy and adolescence. the aim of this study was to evaluate the effects of multidisciplinary short-term therapy on ghrelin and leptin concentrations, bulimia nervosa symptoms, binge eating disorder symptoms, body composition, and visceral and subcutaneous fat in obese adolescents. Methods: Twenty obese adolescents with simple obesity (BMI > 95th percentile, 36.93 +/- 4.14, CDC) were submitted to multidisciplinary ( nutrition, psychology, exercise and clinical) therapy. Plasma ghrelin and leptin concentrations were measured by radioimmunoassay. Bulimic and binge eating behaviors were measured by the Bulimic Investigation Test Edinburgh and the Binge Eating Scale, respectively. Visceral and subcutaneous fat were measured by ultrasonography and body composition by plethysmography. Results: Significant reductions were observed in body weight (101.04 +/- 11.18 to 94.79 +/- 10.94 kg), BMI (36.93 +/- 4.14 to 34.27 +/- 4.78), fat% (41.96 +/- 6.28 to 39.14 +/- 7.62%), visceral fat (4.34 +/- 1.53 to 3.41 +/- 1.12 cm), leptin concentration (20.12 +/- 6.47 to 16.68 +/- 8.08 ng/ml), prevalence of bulimia nervosa (100 to 67%) and binge eating disorder symptoms (40 to 17%). Conclusion: Short-term multidisciplinary therapy was effective in improving body composition, visceral fat, leptinemia and eating disorders in obese adolescents. Copyright (C) 2008 S. Karger AG, Basel.en
dc.description.affiliationUniversidade Federal de São Paulo, CEPE GEO, Post Grad Program Nutr, BR-04020060 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, BR-04020060 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, BR-04020060 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Hlth Sci, BR-04020060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, CEPE GEO, Post Grad Program Nutr, BR-04020060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, BR-04020060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, BR-04020060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Hlth Sci, BR-04020060 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent79-84
dc.identifierhttps://dx.doi.org/10.1159/000139148
dc.identifier.citationHormone Research. Basel: Karger, v. 70, n. 2, p. 79-84, 2008.
dc.identifier.doi10.1159/000139148
dc.identifier.issn0301-0163
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/30356
dc.identifier.wosWOS:000257518300003
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofHormone Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.karger.com/Services/RightsPermissions
dc.subjectLeptinen
dc.subjectGhrelinen
dc.subjectBinge eating disorderen
dc.subjectBulimia nervosaen
dc.subjectBody compositionen
dc.titleHormonal alteration in obese adolescents with eating disorder: Effects of multidisciplinary therapyen
dc.typeinfo:eu-repo/semantics/article
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