Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice

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dc.contributor.authorMoura Estevao, Ligia Reis
dc.contributor.authorSimoes, Ricardo Santos [UNIFESP]
dc.contributor.authorCassini-Vieira, Puebla
dc.contributor.authorCampos Canesso, Maria Cecilia
dc.contributor.authorBarcelos, Luciola da Silva
dc.contributor.authorRachid, Milene Alvarenga
dc.contributor.authorGomes da Cmara, Claudio Augusto
dc.contributor.authorEvencio-Neto, Joaquim
dc.date.accessioned2019-08-19T11:48:27Z
dc.date.available2019-08-19T11:48:27Z
dc.date.issued2017
dc.description.abstractPurpose: To investigated the inflammatory, angiogenic and fibrogenic activities of the Schinus terebinthifolius Raddi leaves oil (STRO) on wound healing. Methods: The excisional wound healing model was used to evaluate the effects of STRO. The mice were divided into two groups: Control, subjected to vehicle solution (ointment lanolin/vaseline base), or STRO-treated group, administered topically once a day for 3, 7 and 14 days post-excision. We evaluated the macroscopic wound closure rateen
dc.description.abstractthe inflammation was evaluated by leukocytes accumulation and cytokine levels in the wounds. The accumulation of neutrophil and macrophages in the wounds were determined by assaying myeloperoxidase and N-acetyl-beta-D-glucosaminidase activities. The levels of TNF-alpha, CXCL-1 and CCL-2 in wound were evaluated by ELISA assay. Angiogenesis and collagen fibers deposition were evaluated histologically. Results: We observed that macroscopic wound closure rate was improved in wounds from STRO-group than Control-group. The wounds treated with STRO promoted a reduction in leucocyte accumulation and in pro-inflammatory cytokine. Moreover, STRO treatment increased significantly the number of blood vessels and collagen fibers deposition, as compared to control group. Conclusion: Topical application of STRO display anti-inflammatory and angiogenic effects, as well as improvement in collagen replacement, suggesting a putative use of this herb for the development of phytomedicines to treat inflammatory diseases, including wound healing.en
dc.description.affiliationUniv Fed Rural Pernambuco UFRPE, Dept Morphol & Anim Physiol, Recife, PE, Brazil
dc.description.affiliationUniv Fed São Paulo UNIFESP, Dept Morphol & Genet, São Paulo, Brazil
dc.description.affiliationUniv Fed Rural Pernambuco, Dept Chem, Recife, PE, Brazil
dc.description.affiliationUniv Fed Rural Pernambuco, Dept Morphol & Anim Physiol, Recife, PE, Brazil
dc.description.affiliationUnifespUniv Fed São Paulo UNIFESP, Dept Morphol & Genet, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo a Ciência e Tecnologia do Estado de Pernambuco (FACEPE)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent726-735
dc.identifierhttp://dx.doi.org/10.1590/s0102-865020170090000005
dc.identifier.citationActa Cirurgica Brasileira. Sao Paulo, v. 32, n. 9, p. 726-735, 2017.
dc.identifier.doi10.1590/s0102-865020170090000005
dc.identifier.fileWOS000412738500005.pdf
dc.identifier.issn0102-8650
dc.identifier.scieloS0102-86502017000900726
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51254
dc.identifier.wosWOS:000412738500005
dc.language.isoeng
dc.publisherActa Cirurgica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectWound Healingen
dc.subjectAngiogenesis Modulating Agentsen
dc.subjectAnti-Inflammatory Agentsen
dc.subjectPhytotherapyen
dc.subjectSkinen
dc.subjectMiceen
dc.titleSchinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in miceen
dc.typeinfo:eu-repo/semantics/article
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