Morphological aspects and Cox-2 expression after exposure to 780-nm laser therapy in injured skeletal muscle: an in vivo study

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dc.contributor.authorRodrigues, Natalia Camargo
dc.contributor.authorBrunelli, Roberta de Matos
dc.contributor.authorAbreu, Daniela Cristina Carvalho de
dc.contributor.authorFernandes, Kelly Rossetti [UNIFESP]
dc.contributor.authorParizotto, Nivaldo Antonio
dc.contributor.authorRenno, Ana Claudia Muniz [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Carlos Departamento de Fisioterapia
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:47:21Z
dc.date.available2015-06-14T13:47:21Z
dc.date.issued2014-10-01
dc.description.abstractBackground:The effectiveness of low-level laser therapy in muscle regeneration is still not well known. Objective: To investigate the effects of laser irradiation during muscle healing.Method: For this purpose, 63 rats were distributed to 3 groups: non-irradiated control group (CG); group irradiated at 10 J/cm² (G10); and group irradiated at 50 J/cm² (G50). Each group was divided into 3 different subgroups (n=7), and on days 7, 14 and 21 post-injury the rats were sacrificed.Results:Seven days post-surgery, the CG showed destroyed zones and extensive myofibrillar degeneration. For both treated groups, the necrosis area was smaller compared to the CG. On day 14 post-injury, treated groups demonstrated better tissue organization, with newly formed muscle fibers compared to the CG. On the 21st day, the irradiated groups showed similar patterns of tissue repair, with improved muscle structure at the site of the injury, resembling uninjured muscle tissue organization. Regarding collagen deposition, the G10 showed an increase in collagen synthesis. In the last period evaluated, both treated groups showed statistically higher values in comparison with the CG. Furthermore, laser irradiation at 10 J/cm2 produced a down-regulation of cyclooxygenase 2 (Cox-2) immunoexpression on day 7 post-injury. Moreover, Cox-2 immunoexpression was decreased in both treated groups on day 14.Conclusions:Laser therapy at both fluencies stimulated muscle repair through the formation of new muscle fiber, increase in collagen synthesis, and down-regulation of Cox-2 expression.en
dc.description.affiliationUniversidade Federal de São Carlos Departamento de Fisioterapia
dc.description.affiliationUniversidade Estadual de Campinas Faculdade de Ciências Médicas Departamento de Cirurgia
dc.description.affiliationUniversidade de São Paulo Departamento de Biomecânica, Medicina e Reabilitação do Sistema Locomotor
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Biociências
dc.description.affiliationUnifespUNIFESP, Depto. de Biociências
dc.description.provenanceMade available in DSpace on 2015-06-14T13:47:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-10-01. Added 1 bitstream(s) on 2015-08-11T04:01:51Z : No. of bitstreams: 1 S1413-35552014000500395.pdf: 2428862 bytes, checksum: 610e7873211ac22c946f92f70237eb6e (MD5)en
dc.description.sourceSciELO
dc.format.extent395-401
dc.identifierhttps://dx.doi.org/10.1590/bjpt-rbf.2014.0057
dc.identifier.citationBrazilian Journal of Physical Therapy. Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia , v. 18, n. 5, p. 395-401, 2014.
dc.identifier.doi10.1590/bjpt-rbf.2014.0057
dc.identifier.fileS1413-35552014000500395.pdf
dc.identifier.issn1413-3555
dc.identifier.scieloS1413-35552014000500395
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/8640
dc.language.isoeng
dc.publisherAssociação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia
dc.relation.ispartofBrazilian Journal of Physical Therapy
dc.rightsAcesso aberto
dc.subjectCollagenen
dc.subjectCryolesionen
dc.subjectCyclooxygenase 2en
dc.subjectInflammation processen
dc.subjectLow-level laser therapyen
dc.subjectPhysical therapyen
dc.titleMorphological aspects and Cox-2 expression after exposure to 780-nm laser therapy in injured skeletal muscle: an in vivo studyen
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