Evaluation of survival of patients with hepatocellular carcinoma: A comparative analysis of prognostic systems

Página do item simplificado
dc.citation.issue4
dc.citation.volumev. 13
dc.contributor.authorTannus, Roberta Kazan [UNIFESP]
dc.contributor.authorAlmeida-Carvalho, S. R. [UNIFESP]
dc.contributor.authorMatos, Carla Adriana Loureiro de [UNIFESP]
dc.contributor.authorGonzalez, Adriano Miziara [UNIFESP]
dc.contributor.authorSalzedas-Netto, Alcides Augusto [UNIFESP]
dc.contributor.authorSzejnfeld, Denis [UNIFESP]
dc.contributor.authorD'Ippolito, Giuseppe [UNIFESP]
dc.contributor.authorLanzoni, Valeria Pereira [UNIFESP]
dc.contributor.authorSouza-Silva, I. [UNIFESP]
dc.coverageSan Francisco
dc.date.accessioned2020-07-20T16:31:01Z
dc.date.available2020-07-20T16:31:01Z
dc.date.issued2018
dc.description.abstractBackground and aim There are several prognostic systems that address different aspects of the patient and the tumour and can guide the management of patients with hepatocellular carcinoma (HCC). This study aimed to evaluate and compare the eight staging systems for a group of patients in a public service in Brazil. Methods Patients with HCC were retrospectively analysed between 2000 and 2012. The prognostic systems Okuda, The Cancer of the Liver Italian Program (CLIP), the Chinese University Prognostic Index (CUPI), Groupe d'Etude et de Traitement du Carcinome Hepatocellulaire (GRETCH), the modified TNM-based Japan Integrated Score (JIS) combined with alpha-fetoprotein and Child-Turcotte-Pugh (CTP), the TNM system, and the Barcelona Clinic Liver Cancer Classification (BCLC) were applied to these patients and compared through model fit measurements, likelihood scores, and the Akaike Information Criterion (AIC). Results A total of 247 patients were studied. The average survival time was 60 months. The TNM, Okuda, CLIP, GRETCH, modified JIS, and BCLC systems were well correlated with one another and individually important to the prediction of survival among the patients studied. However, in the statistical analysis, the CUPI delivered the best predictive performance (AIC = 566en
dc.description.abstractlog-likelihood =-281,240). Conclusion Although the CUPI system was demonstrated to be the most appropriate HCC staging system for the studied population, the choice of an ideal system is a controversial subject, andfuture studies with larger numbers of patients are necessary for the validation of the CUPI system as the method of choice for other populations.en
dc.description.affiliationFed Univ Sao Paulo Unifesp, Hepatol Unit, Dept Gastroenterol, Sao Paulo, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo Unifesp, Liver Transplant Unit, Dept Surg, Sao Paulo, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo Unifesp, Dept Pediat Surg, Sao Paulo, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo Unifesp, Dept Diagnost Radiol, Sao Paulo, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo Unifesp, Dept Diagnost Pathol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo Unifesp, Hepatol Unit, Dept Gastroenterol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo Unifesp, Liver Transplant Unit, Dept Surg, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo Unifesp, Dept Pediat Surg, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo Unifesp, Dept Diagnost Radiol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo Unifesp, Dept Diagnost Pathol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0194922
dc.identifier.citationPlos One. San Francisco, v. 13, n. 4, p. -, 2018.
dc.identifier.doi10.1371/journal.pone.0194922
dc.identifier.fileWOS000429203800056.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55645
dc.identifier.wosWOS:000429203800056
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleEvaluation of survival of patients with hepatocellular carcinoma: A comparative analysis of prognostic systemsen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000429203800056.pdf
Tamanho:
2.36 MB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos