Emergence of pathogenicity in the Sporothrix schenckii complex

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dc.contributor.authorRodrigues, Anderson Messias [UNIFESP]
dc.contributor.authorDe Hoog, Sybren
dc.contributor.authorCamargo, Zoilo Pires de [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCBS KNAW Fungal Biodivers Ctr
dc.date.accessioned2016-01-24T14:31:39Z
dc.date.available2016-01-24T14:31:39Z
dc.date.issued2013-05-01
dc.description.abstractSporothrix schenckii sensu lato is a complex of thermally dimorphic species whose natural habitats are soil and plant materials. However, the traumatic implantation of the species into human skin is traditionally thought to be the route leading to the fungal disease sporotrichosis. the complex contains Sporotrhix mexicana, S. globosa, S. brasiliensis, S. luriei, in addition to S. schenckii sensu stricto. in this study we evaluated the differences among these species relative to their frequency in the environment and in human hosts, as well as discuss their remarkable diverse pathogenicity. Today, S. brasiliensis is epidemic in and geographically restricted to Brazil. in contrast, S. mexicana and S. globosa have rarely been reported over the decades. We discovered that the species have been present in collections from clinical cases since 1955 and were able to re-identify six isolates originally classified as S. schenckii as Sporothrix mexicana (three isolates) and Sporothrix globosa (three isolates). Despite their long presence as potential human pathogens they have not shown any increase in frequency as etiologic agents of human infections.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, Cellular Biol Div, BR-04023062 São Paulo, Brazil
dc.description.affiliationCBS KNAW Fungal Biodivers Ctr, Utrecht, Netherlands
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, Cellular Biol Div, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 2011/07350-1
dc.description.sponsorshipIDCAPES: BEX 2325/11-0
dc.description.sponsorshipIDFAPESP: 2009/54024-2
dc.format.extent405-412
dc.identifierhttp://dx.doi.org/10.3109/13693786.2012.719648
dc.identifier.citationMedical Mycology. London: Informa Healthcare, v. 51, n. 4, p. 405-412, 2013.
dc.identifier.doi10.3109/13693786.2012.719648
dc.identifier.issn1369-3786
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36263
dc.identifier.wosWOS:000317592600009
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofMedical Mycology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.subjectSporothrix mexicanaen
dc.subjectSporothrix globosaen
dc.subjectSporothrix schenckii complexen
dc.subjectsporotrichosisen
dc.subjectcalmodulinen
dc.subjectfirst isolationen
dc.subjectBrazilen
dc.titleEmergence of pathogenicity in the Sporothrix schenckii complexen
dc.typeinfo:eu-repo/semantics/article
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