CRF family peptides are differently altered by acute restraint stress and chronic unpredictable stress

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dc.contributor.authorAndrade, José Simões de [UNIFESP]
dc.contributor.authorViana, Milena de Barros [UNIFESP]
dc.contributor.authorAbrão, Renata Oliveira [UNIFESP]
dc.contributor.authorBittencourt, Jackson C.
dc.contributor.authorCéspedes, Isabel Cristina [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:37:48Z
dc.date.available2016-01-24T14:37:48Z
dc.date.issued2014-09-01
dc.description.abstractCorticotropin-releasing factor (CRF) acts to promote stress-like physiological and behavioral responses and is mainly expressed in the paraventricular hypothalamic nucleus (PVN). Urocortin 1 (Ucn1) is also a ligand to CRF type 1 and 2 receptors that has been associated with the stress response. Ucnl neurons are primarily found in the Edinger-Westphal (EW) nucleus. It has been previously proposed that CRF and Ucnl differently modulate stress responses to distinct types of stressors. the present study used male Wistar rats to compare the effects of acute restraint stress and unpredictable chronic stress (UCS) through Fos-immunoreactivity (Fos-ir) on CRF-containing neurons of PVN and Ucn1-containing EW centrally projecting neurons. Results showed that PVN neurons responded to both acute restraint and UCS. Also for the PVN, unspecific variables, dependent on the time animals remained in the laboratory, do not seem to alter Fos-ir, since no significant differences between acute and chronic control groups were found. On the other hand, EW neurons were only activated in response to acute restraint stress. Also, for this nucleus a significant difference was found between acute and chronic control groups, suggesting that unspecific variables, dependent on the time animals remain in the laboratory, interfere with the nucleus activation. These results suggest that CRF/Ucn1 neuronal circuits encompass two interconnected systems, which are coordinated to respond to acute stressors, but are differentially activated during chronic unpredictable stress. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biosci, UNIFESP, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUniv São Paulo, USP, Inst Biomed Sci, Dept Anat,Lab Chem Neuroanat, BR-05508000 São Paulo, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Psychol, Ctr Neurosci & Behav, BR-05508030 São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosci, UNIFESP, BR-11060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent302-308
dc.identifierhttps://dx.doi.org/10.1016/j.bbr.2014.06.014
dc.identifier.citationBehavioural Brain Research. Amsterdam: Elsevier B.V., v. 271, p. 302-308, 2014.
dc.identifier.doi10.1016/j.bbr.2014.06.014
dc.identifier.issn0166-4328
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/38155
dc.identifier.wosWOS:000340323000040
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBehavioural Brain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectCRFen
dc.subjectUrocortin 1en
dc.subjectParaventricular hypothalamic nucleusen
dc.subjectEdinger-Westphal nucleusen
dc.subjectStressen
dc.titleCRF family peptides are differently altered by acute restraint stress and chronic unpredictable stressen
dc.typeinfo:eu-repo/semantics/article
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