Automated Quantitation of Choroidal Neovascularization: A Comparison Study Between Spectral-Domain and Swept-Source OCT Angiograms

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dc.citation.issue3
dc.citation.volume58
dc.contributor.authorZhang, Qinqin
dc.contributor.authorChen, Chieh-Li
dc.contributor.authorChu, Zhongdi
dc.contributor.authorZheng, Fang
dc.contributor.authorMiller, Andrew
dc.contributor.authorRoisman, Luiz [UNIFESP]
dc.contributor.authorDias, Joao Rafael de Oliveira
dc.contributor.authorYehoshua, Zohar
dc.contributor.authorSchaal, Karen B.
dc.contributor.authorFeuer, William
dc.contributor.authorGregori, Giovanni
dc.contributor.authorKubach, Sophie
dc.contributor.authorAn, Lin
dc.contributor.authorStetson, Paul F.
dc.contributor.authorDurbin, Mary K.
dc.contributor.authorRosenfeld, Philip J.
dc.contributor.authorWang, Ruikang K.
dc.coverageRockville
dc.date.accessioned2020-07-17T14:02:47Z
dc.date.available2020-07-17T14:02:47Z
dc.date.issued2017
dc.description.abstractPURPOSE. To compare the lesion sizes of choroidal neovascularization (CNV) imaged with spectral-domain (SD) and swept-source (SS) optical coherence tomography angiography (OCTA) and measured using an automated detection algorithm. METHODS. Patients diagnosed with CNV were imaged by SD-OCTA and SS-OCTA systems using 3 x 3-mm and 6 x 6-mm scans. The complex optical microangiography (OMAG(C)) algorithm was used to generate the OCTA images. Optical coherence tomography A datasets for imaging CNV were derived by segmenting from the outer retina to 8 mu m below Bruch's membrane. An artifact removal algorithm was used to generate angiograms free of retinal vessel projection artifacts. An automated detection algorithm was developed to quantify the size of the CNV. Automated measurements were compared with manual measurements. Measurements from SD-OCTA and SS-OCTA instruments were compared as well. RESULTS. Twenty-seven eyes from 23 subjects diagnosed with CNV were analyzed. No significant differences were detected between manual and automatic measurements: SD-OCTA 3 x 3-mm (P = 0.61, paired t-test) and 6 x 6-mm (P = 0.09, paired t-test) scans and the SS-OCTA 3 x 3-mm (P = 0.41, paired t-test) and 6 x 6-mm (P = 0.16, paired t-test) scans. Bland-Altman analyses were performed to confirm the agreement between automatic and manual measurements. Mean lesion sizes were significantly larger for the SS-OCTA images compared with the SD-OCTA images: 3 3 3-mm scans (P = 0.011, paired sample t-test) and the 6 x 6-mm scans (P = 0.021, paired t-test). CONCLUSIONS. The automated algorithm measurements of CNV were in agreement with the hand-drawn measurements. On average, automated SS-OCTA measurements were larger than SD-OCTA measurements and consistent with the results from using hand-drawn measurements.en
dc.description.affiliationUniv Washington, Dept Bioengn, 3720 NE 15th Ave, Seattle, WA 98195 USA
dc.description.affiliationUniv Miami, Miller Sch Med, Bascom Palmer Eye Inst, Dept Ophthalmol, Miami, FL 33136 USA
dc.description.affiliationUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.affiliationCarl Zeiss Meditec Inc, Adv Dev, Dublin, CA USA
dc.description.affiliationUniv Washington, Dept Ophthalmol, 3720 NE 15th Ave, Seattle, WA 98195 USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCarl Zeiss Meditec, Inc. (Dublin, CA)
dc.description.sponsorshipNational Eye Institute
dc.description.sponsorshipResearch to Prevent Blindness, Inc., New York, New York
dc.description.sponsorshipNational Eye Institute Center Core Grant
dc.description.sponsorshipCAPES Foundation, Ministry of Education of Brazil, Brasilia-Brazil
dc.description.sponsorshipGerman Research Foundation (DFG)
dc.description.sponsorshipResearch to Prevent Blindness
dc.description.sponsorshipIDNational Eye Institute: R01EY024158
dc.description.sponsorshipIDNational Eye Institute Center Core Grant: P30EY014801
dc.description.sponsorshipIDGerman Research Foundation (DFG): SCHA 1869/1-1
dc.format.extent1506-1513
dc.identifierhttp://dx.doi.org/10.1167/iovs.16-20977
dc.identifier.citationInvestigative Ophthalmology & Visual Science. Rockville, v. 58, n. 3, p. 1506-1513, 2017.
dc.identifier.doi10.1167/iovs.16-20977
dc.identifier.fileWOS000398089000019.pdf
dc.identifier.issn0146-0404
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55012
dc.identifier.wosWOS:000398089000019
dc.language.isoeng
dc.publisherAssoc Research Vision Ophthalmology Inc
dc.relation.ispartofInvestigative Ophthalmology & Visual Science
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectoptical coherence tomographyen
dc.subjectswept-source OCTAen
dc.subjectspectral-domain OCTAen
dc.subjectneovascular AMDen
dc.subjectmacular neovascularizationen
dc.subjectpigment epithelium detachmenten
dc.titleAutomated Quantitation of Choroidal Neovascularization: A Comparison Study Between Spectral-Domain and Swept-Source OCT Angiogramsen
dc.typeinfo:eu-repo/semantics/article
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