Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents

Página do item simplificado
dc.contributor.authorLira, Fabio Santos de [UNIFESP]
dc.contributor.authorRosa Neto, José Cesar [UNIFESP]
dc.contributor.authorPimentel, Gustavo Duarte [UNIFESP]
dc.contributor.authorSantos, Ronaldo Vagner Thomatieli dos [UNIFESP]
dc.contributor.authorCarnier, June [UNIFESP]
dc.contributor.authorSanches, Priscila de Lima [UNIFESP]
dc.contributor.authorPiano, Aline de [UNIFESP]
dc.contributor.authorSouza, Claudio T. de
dc.contributor.authorTock, Lian [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorSeelaender, Marilia Cerqueira Leite [UNIFESP]
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorDâmaso, Ana Raimunda [UNIFESP]
dc.contributor.institutionDept Fisiol
dc.contributor.institutionDept Biociencias
dc.contributor.institutionDept Psicobiol
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv So Santa Catarina
dc.date.accessioned2016-01-24T14:27:42Z
dc.date.available2016-01-24T14:27:42Z
dc.date.issued2012-09-18
dc.description.abstractAim: the purpose of the present study was to assess the dietary fat intake, glucose, insulin, Homeostasis model assessment for insulin resistance HOMA-IR, and endotoxin levels and correlate them with adipokine serum concentrations in obese adolescents who had been admitted to long-term interdisciplinary weight-loss therapy.Design: the present study was a longitudinal clinical intervention of interdisciplinary therapy. Adolescents (n = 18, aged 15-19 y) with a body mass index >95th percentile were admitted and evaluated at baseline and again after 1 year of interdisciplinary therapy. We collected blood samples, and IL-6, adiponectin, and endotoxin concentrations were measured by ELISA. Food intake was measured using 3-day diet records. in addition, we assessed glucose and insulin levels as well as the homeostasis model assessment for insulin resistance (HOMA-IR).Results: the most important finding from the present investigation was that the long-term interdisciplinary lifestyle therapy decreased dietary fat intake and endotoxin levels and improved HOMA-IR. We observed positive correlations between dietary fat intake and endotoxin levels, insulin levels, and the HOMA-IR. in addition, endotoxin levels showed positive correlations with IL-6 levels, insulin levels and the HOMA-IR. Interestingly, we observed a negative correlation between serum adiponectin and both dietary fat intake and endotoxin levels.Conclusions: the present results indicate an association between dietary fat intake and endotoxin level, which was highly correlated with a decreased pro-inflammatory state and an improvement in HOMA-IR. in addition, this benefits effect may be associated with an increased adiponectin level, which suggests that the interdisciplinary therapy was effective in improving inflammatory pathways.en
dc.description.affiliationDept Fisiol, São Paulo, Brazil
dc.description.affiliationDept Biociencias, São Paulo, Brazil
dc.description.affiliationDept Psicobiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, São Paulo, Brazil
dc.description.affiliationICB Univ São Paulo USP, Grp Metab & Canc, São Paulo, Brazil
dc.description.affiliationUniv So Santa Catarina, Hlth Sci Unit, Lab Exercise Biochem & Physiol, Criciuma, SC, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2011/50356-0
dc.description.sponsorshipIDFAPESP: 2011/50414-0
dc.format.extent7
dc.identifierhttps://dx.doi.org/10.1186/1475-2891-11-74
dc.identifier.citationNutrition Journal. London: Biomed Central Ltd, v. 11, 7 p., 2012.
dc.identifier.doi10.1186/1475-2891-11-74
dc.identifier.fileWOS000310462200001.pdf
dc.identifier.issn1475-2891
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/35277
dc.identifier.wosWOS:000310462200001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofNutrition Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectObesityen
dc.subjectCytokinesen
dc.subjectEndotoxinen
dc.subjectInsulin resistanceen
dc.subjectInterdisciplinary therapyen
dc.titleLong-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescentsen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000310462200001.pdf
Tamanho:
365.31 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos