Abnormal brain oscillations persist after recovery from bipolar depression

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dc.citation.volume41
dc.contributor.authorCanali, P.
dc.contributor.authorCasarotto, S.
dc.contributor.authorRosanova, M.
dc.contributor.authorSferrazza-Papa, G.
dc.contributor.authorCasali, A. G. [UNIFESP]
dc.contributor.authorGosseries, O.
dc.contributor.authorMassimini, M.
dc.contributor.authorSmeraldi, E.
dc.contributor.authorColombo, C.
dc.contributor.authorBenedetti, F.
dc.coverageParis
dc.date.accessioned2020-07-17T14:02:53Z
dc.date.available2020-07-17T14:02:53Z
dc.date.issued2017
dc.description.abstractWhen directly perturbed in healthy subjects, premotor cortical areas generate electrical oscillations in the beta range (20-40 Hz). In schizophrenia, major depressive disorder and bipolar disorder (BD), these oscillations are markedly reduced, in terms of amplitude and frequency. However, it still remains unclear whether these abnormalities can be modulated over time, or if they can be still observed after treatment. Here, we employed transcranial magnetic stimulation (TMS) combined with EEG to assess the frontal oscillatory activity in eighteen BD patients before/after antidepressant treatments (sleep deprivation and light therapy), relative to nine healthy controls. In order to detect dominant frequencies, event related spectral perturbations (ERSP) were computed for each TMS/EEG session in all participants, using wavelet decomposition. The natural frequency at which the cortical circuit oscillates was calculated as the frequency value with the largest power across 300 ms post-stimulus time interval. Severity of depression markedly decreased after treatment with 12 patients achieving response and nine patients achieving remission. TMS/EEG resulted in a significant activation of the beta/gamma band response (2150 Hz) in healthy controls. In patients, the main frequencies of premotor EEG responses to TMS did not significantly change before/after treatment and were always significantly lower than those of controls (11-27 Hz) and comparable in patients achieving remission and in those not responding to treatment. These results suggest that the reduction of natural frequencies is a trait marker of BD, independent from the clinical status of the patients. The present findings shed light on the neurobiological underpinning of severe psychiatric disorders and demonstrate that TMS/EEG represents a unique tool to develop biomarkers in psychiatry. (C) 2016 Elsevier Masson SAS. All rights reserved.en
dc.description.affiliationUniv Vita Salute San Raffaele, Dept Clin Neurosci, Sci Inst Osped San Raffaele, 20 Via Stamira dAncona, I-20127 Milan, Italy
dc.description.affiliationUniv Milan, Dept Biomed & Clin Sci L Sacco, Milan, Italy
dc.description.affiliationUniv Hosp Liege, GIGA Res & Neurol Dept, Coma Sci Grp, Liege, Belgium
dc.description.affiliationUniv Wisconsin, Dept Psychiat & Psychol, Postle Lab, Ctr Sleep & Consciousness, Madison, WI USA
dc.description.affiliationFdn Europea Ric Biomed, FERB Onlus, Milan, Italy
dc.description.affiliationUniv Fed Sao Paulo, Inst Sci & Technol, 330 Rua Talim, Sao Jose Dos Campos, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Inst Sci & Technol, 330 Rua Talim, Sao Jose Dos Campos, Brazil
dc.description.sourceWeb of Science
dc.format.extent10-15
dc.identifierhttp://dx.doi.org/10.1016/j.eurpsy.2016.10.005
dc.identifier.citationEuropean Psychiatry. Paris, v. 41, p. 10-15, 2017.
dc.identifier.doi10.1016/j.eurpsy.2016.10.005
dc.identifier.issn0924-9338
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55065
dc.identifier.wosWOS:000397668400003
dc.language.isoeng
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier
dc.relation.ispartofEuropean Psychiatry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectTMS/EEGen
dc.subjectGamma oscillationsen
dc.subjectBiomarkersen
dc.subjectBipolar disorderen
dc.subjectGABAergic circuitsen
dc.titleAbnormal brain oscillations persist after recovery from bipolar depressionen
dc.typeinfo:eu-repo/semantics/article
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