Raynaud's syndrome in children: systematic review and development of recommendations for assessment and monitoring

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dc.contributor.authorPain, C. E.
dc.contributor.authorConstantine, T.
dc.contributor.authorToplak, N.
dc.contributor.authorMoll, M.
dc.contributor.authorIking-Konert, C.
dc.contributor.authorPiotto, D. P. [UNIFESP]
dc.contributor.authorAyaz, N. Aktay
dc.contributor.authorNemcova, D.
dc.contributor.authorHoeger, P. H.
dc.contributor.authorCutolo, M.
dc.contributor.authorSmith, V.
dc.contributor.authorFoeldvari, I.
dc.date.accessioned2019-07-22T15:46:44Z
dc.date.available2019-07-22T15:46:44Z
dc.date.issued2016
dc.description.abstractObjective. To develop recommendations for investigation and monitoring of children with Raynaud's syndrome, based on paediatric evidence collated by a systematic review. Method. A systematic review was undertaken to establish the paediatric evidence for assessment and monitoring of Raynaud's syndrome. An expert panel including members of the Paediatric Rheumatology European Society (PRES) Scleroderma Working Group, were invited to a consensus meeting where recommendations were developed based on evidence graded by the systematic review and where evidence was lacking, consensus opinion. A nominal technique was used where 75% consensus was taken as agreement. Results. The expert panel recommended testing anti-nuclear antibody (ANA), more specific antibodies associated with connective tissue disease and nail-fold capillaroscopy in all children presenting with Raynaud's syndrome as data suggests these can be risk factors for evolution into a connective tissue disease. The frequency of follow-up recommended depends on presence of these risk factors with the aim to detect evolving connective tissue disease early in high risk individuals. Those with no abnormalities on capillaroscopy and negative autoantibodies were deemed low risk of progression, whereas those with ANA positivity, specific autoantibodies and/or nailfold capillary changes were deemed high risk and more frequent follow-up was recommended. Conclusion. Recommendations, primarily based on consensus opinion, were agreed regarding investigation and monitoring of children who present with Raynaud's syndrome. Further prospective studies are needed to better define the risk factors for progression to connective tissue disease.en
dc.description.affiliationAlder Hey Childrens NHS Fdn Trust, Liverpool, Merseyside, England
dc.description.affiliationSemmelweis Univ, Budapest, Hungary
dc.description.affiliationUniv Childrens Hosp Ljubljana, Ljubljana, Slovenia
dc.description.affiliationUniv Childrens Hosp, Tubingen, Germany
dc.description.affiliationUniv Klinikum Hamburg Eppendorf, Hamburg, Germany
dc.description.affiliation[Piotto, D. P.] Univ Fed Sao Paulo, Sao Paulo, Brazil
dc.description.affiliationIstanbul Kanuni Sultan Suleyman Educ & Res Hosp, Istanbul, Turkey
dc.description.affiliationCharles Univ Prague, Prague, Czech Republic
dc.description.affiliationCath Childrens Hosp, Dept Paediat Dermatol, Hamburg, Germany
dc.description.affiliationUniv Genoa, Genoa, Italy
dc.description.affiliationGhent Univ Hosp, Ghent, Belgium
dc.description.affiliationHamburger Zentrum Kinder & Jugendrheumatol, Hamburg, Germany
dc.description.affiliationUnifespUniv Fed Sao Paulo, EPM, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extentS200-S206
dc.identifier.citationClinical And Experimental Rheumatology. Pisa, v. 34, n. 5, p. S200-S206, 2016.
dc.identifier.issn0392-856X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51057
dc.identifier.wosWOS:000387095400032
dc.language.isoeng
dc.publisherClinical & Exper Rheumatology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectRaynaud's diseaseen
dc.subjectchilden
dc.subjectadolescenten
dc.subjectautoantibodiesen
dc.subjectmicroscopic angioscopyen
dc.titleRaynaud's syndrome in children: systematic review and development of recommendations for assessment and monitoringen
dc.typeinfo:eu-repo/semantics/review
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