Macrovascular disease in a Japanese-Brazilian population of high prevalence of metabolic syndrome: Associations with classical and non-classical risk factors

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dc.contributor.authorSiqueira, Antonela F. A.
dc.contributor.authorFranco, Laercio J.
dc.contributor.authorGimeno, Suely G. A.
dc.contributor.authorMatsumura, Luiza K.
dc.contributor.authorAbdalla, Dulcineia S. P.
dc.contributor.authorBarros, Newton de
dc.contributor.authorFerreira, Sandra R. G.
dc.contributor.authorJBDSG
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T13:49:11Z
dc.date.available2016-01-24T13:49:11Z
dc.date.issued2007-11-01
dc.description.abstractBackground: the Japanese-Brazilian Diabetes Study detected high prevalence of metabolic syndrome (MS) in a population of Japanese ancestry living in Brazil. We describe the prevalence of macrovascular disease (MVD) and its association with classical and non-classical cardiovascular risk factors in this population.Methods: An overall of 1163 individuals were studied; diagnosis of MVD was based on a score obtained from medical history, ankle-brachial pressure index and electrocardiogram, defining three groups: no MVD, possible MVD and definite MVD.Results: Prevalence of MVD was 14.3% (possible MVD: 11.2%; definite MVD: 3.1%). Individuals with MS had higher rates of MVD (16.9% versus 11.2%; p < 0.05). Comparing to no MVD, age, 2 It plasma glucose, anti-LDL(+) and anti-LDL(-) levels, and urinary albumin-to-creatinine ratio were higher in both categories with MVD; waist-to-hip ratio, fasting plasma glucose, HbAlc, total-to-HDL cholesterol ratio and triglycerides were higher in that with definite MVD; systolic blood pressure and homocysteine were higher in that with possible MVD. Using logistic regression, systolic blood pressure, smoking habit and anti-LDL(+) were independently associated with MVD.Conclusion: MVD is highly prevalent in Japanese-Brazilians and its association with MS was confirmed. A novel marker of lipoprotein modifications-anti-LDL(+) antibody-could be useful in identifying individuals at higher risk. (c) 2006 Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Internal Med, Div Endocrinol, BR-05508 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Ribeirao Preto Med Sch, Dept Social & Prevent Med, BR-05508 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Prevent Med, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Clin & Toxicol Anal, BR-05508 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Publ Hlth, Dept Nutr, BR-05508 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Surg, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Internal Med, Div Endocrinol, BR-05508 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Prevent Med, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Surg, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent160-166
dc.identifierhttp://dx.doi.org/10.1016/j.atherosclerosis.2006.09.012
dc.identifier.citationAtherosclerosis. Clare: Elsevier B.V., v. 195, n. 1, p. 160-166, 2007.
dc.identifier.doi10.1016/j.atherosclerosis.2006.09.012
dc.identifier.issn0021-9150
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30121
dc.identifier.wosWOS:000251046100021
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAtherosclerosis
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectmacrovascular diseaseen
dc.subjectmetabolic syndromeen
dc.subjectcardiovascular risk factorsen
dc.subjectAnti-LDL antibodiesen
dc.subjectJapanese-Braziliansen
dc.titleMacrovascular disease in a Japanese-Brazilian population of high prevalence of metabolic syndrome: Associations with classical and non-classical risk factorsen
dc.typeinfo:eu-repo/semantics/article
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