Cranial radiotherapy predisposes to abdominal adiposity in survivors of childhood acute lymphocytic leukemia

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dc.contributor.authorSiviero-Miachon, Adriana Aparecida [UNIFESP]
dc.contributor.authorSpinola-Castro, Angela Maria [UNIFESP]
dc.contributor.authorLee, Maria Lucia de Martino
dc.contributor.authorAndreoni, Solange [UNIFESP]
dc.contributor.authorGeloneze, Bruno
dc.contributor.authorLederman, Henrique [UNIFESP]
dc.contributor.authorGuerra-Junior, Gil
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionIOP GRAACC
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2016-01-24T14:31:16Z
dc.date.available2016-01-24T14:31:16Z
dc.date.issued2013-02-21
dc.description.abstractBackground: Advances in treatment of acute lymphocytic leukemia increased the likelihood of developing late treatment-associated effects, such as abdominal adiposity, increasing the risk of cardiovascular disease in this population. Cranial radiotherapy is one of the factors that might be involved in this process. the aim of this study was to determine the effect of cranial radiotherapy on adiposity indexes in survivors of acute lymphocytic leukemia.Methods: A comparative cross-sectional study of 56 acute lymphocytic leukemia survivors, chronological age between 15 and 24 years, assigned into two groups according to the exposure to cranial radiotherapy (25 irradiated and 31 non-irradiated), assessed according to body fat (dual energy X-ray absorptiometry), computed tomography scan-derived abdominal adipose tissue, lipid profile, and insulin resistance.Results: Cranial radiotherapy increased body fat and abdominal adipose tissue and altered lipid panel. Yet, lipids showed no clinical relevance so far. There were significantly more obese patients among those who received cranial radiotherapy (52% irradiated versus 22.6% non-irradiated), based on dual energy X-ray absorptiometry body fat measurements. Nonetheless, no association was observed between cranial radiotherapy and body mass index, waist circumference, waist-to-height ratio or insulin resistance.Conclusions: Adolescent and young adult survivors of childhood acute lymphocytic leukemia showed an increase in body fat and an alteration of fat distribution, which were related to cranial radiotherapy. Fat compartment modifications possibly indicate a disease of adipose tissue, and cranial radiotherapy imports in this process.en
dc.description.affiliationUniversidade Federal de São Paulo, Div Pediat Endocrinol, Dept Pediat, UNIFESP EPM, São Paulo, Brazil
dc.description.affiliationIOP GRAACC, Pediat Oncol Inst, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Prevent & Social Med, Div Biostat, UNIFESP EPM, São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Lab Invest Metab & Diabet LIMED, Fac Med Sci, UNICAMP, Campinas, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Diagnost Imaging, UNIFESP EPM, São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Pediat, Div Pediat Endocrinol, Fac Med Sci,UNICAMP, Campinas, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Pediat Endocrinol, Dept Pediat, UNIFESP EPM, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Prevent & Social Med, Div Biostat, UNIFESP EPM, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Diagnost Imaging, UNIFESP EPM, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 06/06162-9
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.1186/1748-717X-8-39
dc.identifier.citationRadiation Oncology. London: Biomed Central Ltd, v. 8, 9 p., 2013.
dc.identifier.doi10.1186/1748-717X-8-39
dc.identifier.fileWOS000317786800001.pdf
dc.identifier.issn1748-717X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35981
dc.identifier.wosWOS:000317786800001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofRadiation Oncology
dc.rightsAcesso aberto
dc.subjectPrecursor cell lymphoblastic leukemia-lymphoma/radiotherapyen
dc.subjectAdiposityen
dc.subjectAbdominal faten
dc.subjectLipid metabolism disordersen
dc.subjectInsulin resistanceen
dc.titleCranial radiotherapy predisposes to abdominal adiposity in survivors of childhood acute lymphocytic leukemiaen
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