Gastroesophageal reflux disease: exaggerations, evidence and clinical practice

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dc.contributor.authorFerreira, Cristina Targa
dc.contributor.authorCarvalho, Elisa de
dc.contributor.authorSdepanian, Vera Lucia [UNIFESP]
dc.contributor.authorMorais, Mauro Batista de [UNIFESP]
dc.contributor.authorVieira, Mario Cesar
dc.contributor.authorSilva, Luciana Rodrigues
dc.contributor.institutionHosp Crianca Santo Antonio
dc.contributor.institutionUniv Fed Ciencias Saade Porto Alegre
dc.contributor.institutionDept Gastroenterol
dc.contributor.institutionHosp Base Distrito Fed
dc.contributor.institutionHosp Crianca Brasilia
dc.contributor.institutionUniversidade de Brasília (UnB)
dc.contributor.institutionDept Pediat Gastroenterol
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Israelita Albert Einstein
dc.contributor.institutionPontificia Univ Catolica Parana
dc.contributor.institutionHosp Pequeno Principe
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.contributor.institutionAcad Brasileira Pediat
dc.date.accessioned2016-01-24T14:35:20Z
dc.date.available2016-01-24T14:35:20Z
dc.date.issued2014-03-01
dc.description.abstractObjective: there are many questions and little evidence regarding the diagnosis and treatment of gastroesophageal reflux disease (GERD) in children. the association between GERD and cow's milk protein allergy (CMPA), overuse of abdominal ultrasonography for the diagnosis of GERD, and excessive pharmacological treatment, especially proton-pump inhibitors (PPIs) are some aspects that need clarification. This review aimed to establish the current scientific evidence for the diagnosis and treatment of GERD in children.Data source: a search was conducted in the MEDLINE, Pub Med, LILACS, SciELO, and Cochrane Library electronic databases, using the following keywords: gastroesophageal reflux; gastroesophageal reflux disease; proton-pump inhibitors; and prokinetics; in different age groups of the pediatric age range; up to May of 2013.Data synthesis: abdominal ultrasonography should not be recommended to investigate gastroesophageal reflux (GER). Simultaneous treatment of GERD and CMPA often results in unnecessary use of medication or elimination diet. There is insufficient evidence for the prescription of prokinetics to all patients with GER/GERD. There is little evidence to support acid suppression in the first year of life, to treat nonspecific symptoms suggestive of GERD. Conservative treatment has many benefits and with low cost and no side-effects.Conclusions: there have been few randomized controlled trials that assessed the management of GERD in children and no examination can be considered the gold standard for GERD diagnosis. for these reasons, there are exaggerations in the diagnosis and treatment of this disease, which need to be corrected. (C) 2013 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.en
dc.description.affiliationHosp Crianca Santo Antonio, Complexo Hosp Santa Casa, Pediat Gastroenterol Serv, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Ciencias Saade Porto Alegre, Dept Pediat, Porto Alegre, RS, Brazil
dc.description.affiliationDept Gastroenterol, Soc Brasileira Pediat, Rio de Janeiro, RJ, Brazil
dc.description.affiliationHosp Base Distrito Fed, Pediat Unit, Brasilia, DF, Brazil
dc.description.affiliationHosp Crianca Brasilia, Brasilia, DF, Brazil
dc.description.affiliationCtr Univ Brasilia, Brasilia, DF, Brazil
dc.description.affiliationDept Pediat Gastroenterol, Soc Brasileira Pediat, Brasilia, DF, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Pediat, São Paulo, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Clin Especialidades Pediat, São Paulo, Brazil
dc.description.affiliationPontificia Univ Catolica Parana, Dept Pediat, Curitiba, PR, Brazil
dc.description.affiliationHosp Pequeno Principe, Pediat Gastroenterol Serv, Curitiba, PR, Brazil
dc.description.affiliationUniv Fed Bahia, Pediat Gastroenterol & Hepatol Serv, Salvador, BA, Brazil
dc.description.affiliationAcad Brasileira Pediat, Rio de Janeiro, RJ, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Pediat, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent105-118
dc.identifierhttp://dx.doi.org/10.1016/j.jped.2013.05.009
dc.identifier.citationJornal de Pediatria. Rio de Janeiro, Rj: Soc Brasil Pediatria, v. 90, n. 2, p. 105-118, 2014.
dc.identifier.doi10.1016/j.jped.2013.05.009
dc.identifier.fileS0021-75572014000200105.pdf
dc.identifier.issn0021-7557
dc.identifier.scieloS0021-75572014000200105
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37454
dc.identifier.wosWOS:000334016100003
dc.language.isoeng
dc.publisherSoc Brasil Pediatria
dc.relation.ispartofJornal de Pediatria
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGastroesophageal reflux diseaseen
dc.subjectGastroesophageal refluxen
dc.subjectProton pump inhibitorsen
dc.subjectProton pump inhibitors/therapeutic useen
dc.subjectInfant Childen
dc.titleGastroesophageal reflux disease: exaggerations, evidence and clinical practiceen
dc.typeinfo:eu-repo/semantics/article
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