Mesenchymal stem cells as therapeutic candidates for halting the progression of diabetic nephropathy

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dc.contributor.authorPaulini, Janaina
dc.contributor.authorHiguti, Eliza
dc.contributor.authorBastos, Rosana M. C.
dc.contributor.authorGomes, Samirah A.
dc.contributor.authorRangel, Erika B. [UNIFESP]
dc.date.accessioned2019-01-21T10:29:39Z
dc.date.available2019-01-21T10:29:39Z
dc.date.issued2016
dc.description.abstractMesenchymal stem cells (MSCs) possess pleiotropic properties that include immunomodulation, inhibition of apoptosis, fibrosis and oxidative stress, secretion of trophic factors, and enhancement of angiogenesis. These properties provide a broad spectrum for their potential in a wide range of injuries and diseases, including diabetic nephropathy (DN). MSCs are characterized by adherence to plastic, expression of the surface molecules CD73, CD90, and CD105 in the absence of CD34, CD45, HLA-DR, and CD14 or CD11b and CD79a or CD19 surface molecules, and multidifferentiation capacity in vitro. MSCs can be derived from many tissue sources, consistent with their broad, possibly ubiquitous distribution. This article reviews the existing literature and knowledge of MSC therapy in DN, as well as the most appropriate rodent models to verify the therapeutic potential of MSCs in DN setting. Some preclinical relevant studies are highlighted and new perspectives of combined therapies for decreasing DN progression are discussed. Hence, improved comprehension and interpretation of experimental data will accelerate the progress towards clinical trials that should assess the feasibility and safety of this therapeutic approach in humans. Therefore, MSC-based therapies may bring substantial benefit for patients suffering from DN.en
dc.description.affiliationSociedade Beneficente Albert Einstein, Albert Einstein Hospital, 05652 São Paulo, SP, Brazil
dc.description.affiliation[University of São Paulo, 01246 São Paulo, SP, Brazil
dc.description.affiliationFederal University of São Paulo, 04023 São Paulo, SP, Brazil
dc.description.affiliationUnifespFederal University of São Paulo, 04023 São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo/Sao Paulo Research Foundation) [2013/19560-6]
dc.description.sponsorshipCNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/National Counsel of Technological and Scientific Development) [456959/2013-0]
dc.description.sponsorshipEFSD (European Foundation for the Study of Diabetes)
dc.description.sponsorshipIDFAPESP: 2013/19560-6
dc.description.sponsorshipIDCNPq: 456959/2013-0
dc.identifierhttp://dx.doi.org/10.1155/2016/9521629
dc.identifier.citationStem Cells International. New york, 2016.
dc.identifier.doi10.1155/2016/9521629
dc.identifier.fileWOS000390552900001.pdf
dc.identifier.issn1687-966X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49309
dc.identifier.wosWOS:000390552900001
dc.language.isoeng
dc.publisherUniv Sao Paulo, Conjunto Quimicas
dc.relation.ispartofStem Cells International
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectUmbilical-Cord Blooden
dc.subjectAmeliorates Glomerular Injuryen
dc.subjectInhibiting Oxidative Stressen
dc.subjectParietal Epithelial-Cellsen
dc.subjectRenal Progenitor Cellsen
dc.subjectChronic Kidney-Diseaseen
dc.subjectBone-Marrowen
dc.subjectStromal Cellsen
dc.subjectMesangial Cellsen
dc.subjectIn-Vitroen
dc.titleMesenchymal stem cells as therapeutic candidates for halting the progression of diabetic nephropathyen
dc.typeinfo:eu-repo/semantics/review
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