Airway obstruction produces widespread sympathoexcitation: role of hypoxia, carotid chemoreceptors, and NTS neurotransmission

Página do item simplificado
dc.citation.issue3
dc.citation.volume6
dc.contributor.authorFerreira, Caroline B. [UNIFESP]
dc.contributor.authorCravo, Sergio L. [UNIFESP]
dc.contributor.authorStocker, Sean D.
dc.coverageHoboken
dc.date.accessioned2020-07-08T13:09:46Z
dc.date.available2020-07-08T13:09:46Z
dc.date.issued2018
dc.description.abstractObstructive sleep apnea (OSA) is the most common respiratory disturbance of sleep and is closely associated to cardiovascular diseases. In humans, apnea increases respiratory effort and elevates muscle sympathetic nerve activity (SNA), but the primary stimulus for the SNA activation has not been identified. We recently developed a model of apnea in rodents using acute airway obstruction. In this study, we employed this model to test whether the elevation in SNA was mediated by hypoxia, carotid chemoreceptors, or neurotransmission in the nucleus tractus solitarius (NTS). In anesthetized, male Sprague-Dawley rats, airway obstruction (20s) increased phrenic nerve activity (PNA), arterial blood pressure (ABP), and lumbar, renal, and splanchnic SNA. The changes in SNA were similar across all three sympathetic nerves. Inactivation of chemoreceptors by hyperoxia (100% O-2) or surgical denervation of carotid chemoreceptors attenuated, but did not eliminate, the changes in SNA and ABP produced by airway obstruction. To interrupt afferent information from carotid chemoreceptor and extracarotid afferents to the hindbrain, airway obstruction was performed before and after NTS microinjection of the GABA(A) agonist muscimol or a cocktail of NMDA and non-NMDA antagonists. Inhibition of NTS neurons or blockade of glutamatergic receptors attenuated the increase in lumbar SNA, splanchnic SNA, renal SNA, and PNA. Collectively, these findings suggest that PNA and SNA responses induced by airway obstruction depend, in part, on chemoreceptors afferents and glutamatergic neurotransmission in the NTS.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Physiol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Pittsburgh, Sch Med, Dept Med, Div Renal Electrolyte, Pittsburgh, PA 15213 USA
dc.description.affiliationUniv Pittsburgh, Sch Med, Hypertens Ctr, Pittsburgh, PA USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Physiol, Sao Paulo, SP, Brazil
dc.description.provenanceMade available in DSpace on 2020-07-08T13:09:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2018. Added 1 bitstream(s) on 2020-07-08T13:33:40Z : No. of bitstreams: 1 WOS000425110700002.pdf: 1364946 bytes, checksum: 07870f54a0183e52b787c33db2150781 (MD5)en
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Heart, Lung, and Blood Institute Grant
dc.description.sponsorshipAmerican Heart Association Established Investigator Award
dc.description.sponsorshipCoordination of Training of Higher Education Graduate Foundation (CAPES)
dc.description.sponsorshipNational Council for Scientific and Technological Development (CNPq)
dc.description.sponsorshipIDNational Heart, Lung, and Blood Institute Grant: R01 HL113270
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.14814/phy2.13536
dc.identifier.citationPhysiological Reports. Hoboken, v. 6, n. 3, p. -, 2018.
dc.identifier.doi10.14814/phy2.13536
dc.identifier.fileWOS000425110700002.pdf
dc.identifier.issn2051-817X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54198
dc.identifier.wosWOS:000425110700002
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofPhysiological Reports
dc.rightsAcesso aberto
dc.subjectApneaen
dc.subjectcarotid chemoreceptorsen
dc.subjectNTSen
dc.subjectsympathetic nerve activityen
dc.titleAirway obstruction produces widespread sympathoexcitation: role of hypoxia, carotid chemoreceptors, and NTS neurotransmissionen
dc.typeArtigo
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000425110700002.pdf
Tamanho:
1.3 MB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos