Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucoma

Página do item simplificado
dc.citation.issue3
dc.citation.volumev. 13
dc.contributor.authorFurlanetto, Rafael Lacerda [UNIFESP]
dc.contributor.authorTeixeira, Sergio Henrique [UNIFESP]
dc.contributor.authorGracitelli, Carolina Pelegrini Barbosa [UNIFESP]
dc.contributor.authorLottenberg, Claudio Luiz [UNIFESP]
dc.contributor.authorEmori, Fabiano
dc.contributor.authorMichelan, Michel
dc.contributor.authorAmaro, Edson, Jr.
dc.contributor.authorParanhos Junior, Augusto [UNIFESP]
dc.coverageSan Francisco
dc.date.accessioned2020-07-20T16:31:14Z
dc.date.available2020-07-20T16:31:14Z
dc.date.issued2018
dc.description.abstractPurpose To analyze the correlation between structural characteristics of intraorbital optic nerve (ION) and lateral geniculate nucleus (LGN) measured by 3-Tesla magnetic resonance imaging (3T MRI), and the severity of glaucomatous damage. Methods In this cross-sectional study, 41 glaucoma patients and 12 age-and sex-matched controls underwent standard automated perimetry (SAP) and frequency doubling technology (FDT) as functional evaluationen
dc.description.abstractoptic disc stereophotograph, spectral-domain optical coherence tomography (OCT) and confocal scanning laser tomography as ocular structural evaluationen
dc.description.abstractand 3T MRI. Structure-structure and structure-function correlation were performed using bootstrap resampling method for clustered data. Results The ION mean diameter and cross-sectional area were different between glaucoma and control groups at 5mm and 10mm (all, p <= 0.011) from the globe, but not at 15mm (both, p >= 0.067). LGN height was significantly lower in glaucoma group (p = 0.005). OCT rim area and functional parameters (SAP and FDT) correlated significantly with all ION segments, showing stronger correlations at 10 and 15 mm. ION parameters at 10 and 15 mm presented mild-to-moderate correlation with OCT peripapillary nerve fiber layer thickness, and ION at 15mm had mild association with the neuroretinal rim area on stereophotographs. Although LGN height was significantly smaller in glaucoma group (p = 0.005), LGN parameters were not associated with any ocular structural or functional parameter. Conclusion Assessment of central and peripheral nervous systems using 3T MRI confirmed that glaucoma patients had smaller ION dimensions and LGN height compared to the control group. In general, ION dimensions presented mild to moderate correlations with functional and ocular structural parameters. Although ION had significant correlations at any distance from the eye, the ION distal locations correlated better with OCT results and functional parameters. However, LGN parameters were not associated with functional or ocular structural parameters.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, SP, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, SP, Brazil
dc.description.provenanceMade available in DSpace on 2020-07-20T16:31:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2018. Added 1 bitstream(s) on 2020-07-20T17:43:17Z : No. of bitstreams: 1 WOS000428168400010.pdf: 7439347 bytes, checksum: 89bb01ac902986dcc8095e536f785d13 (MD5)en
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) Foundation, Ministry of Education of Brazil
dc.description.sponsorshipIDCAPES: 9033/11-4
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0194038
dc.identifier.citationPlos One. San Francisco, v. 13, n. 3, 2018.
dc.identifier.doi10.1371/journal.pone.0194038
dc.identifier.fileWOS000428168400010.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55803
dc.identifier.wosWOS:000428168400010
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsAcesso aberto
dc.titleStructural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucomaen
dc.typeArtigo
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000428168400010.pdf
Tamanho:
7.09 MB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos