Decreased GH secretion and enhanced ACTH and cortisol release after ghrelin administration in Cushing's disease: comparison with GHRP-6

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dc.contributor.authorCorrea-Silva, Silvia Regina [UNIFESP]
dc.contributor.authorNascif, Sergio Oliva [UNIFESP]
dc.contributor.authorSilva, Marcos Roberto
dc.contributor.authorBorges, Maria Helena Senger
dc.contributor.authorMiranda, W. L.
dc.contributor.authorMachado, A. F.
dc.contributor.authorLengyel, Ana Maria Judith [UNIFESP]
dc.contributor.authorMEDIMOND
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T11:27:11Z
dc.date.available2018-06-18T11:27:11Z
dc.date.issued2004-01-01
dc.description.abstractGHRP-6-induced GH release is decreased in Cushing's disease (CD), and ACTH and cortisol responses are enhanced. Ghrelin stimulates GH, ACTH and cortisol release in men. We compared the GH, ACTH and cortisol responses to ghrelin and GHRP-6 in CD (n = 12) and controls (n = 9). In CD, peak GH levels (mu g/L; mean +/- SE) after ghrelin administration (7,7 +/- 2,6) were higher than those observed after GHRP-6 (2,7 +/- 1), but lower than in controls (58,4 +/- 10). Peak ACTH (pg/mL) and cortisol (mu g/dL) levels after ghrelin (187 +/- 35 +/- 4,5) were higher than in controls (93 +/- 32; 18,9 +/- 1,1), but similar to GHRP-6 (185 +/- 57; 33,3 +/- 4,7). The higher GH response to ghrelin compared to GHRP-6 in CD suggests activation of additional intracellular pathways by ghrelin. The same ACTH and cortisol releasing mechanisms are probably stimulated by both peptides.en
dc.description.affiliationUniv Fed Sao Paulo, Div Endocrinol, EPM, FAPESP,CNPq, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Endocrinol, EPM, FAPESP,CNPq, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent913-917
dc.identifier.citationProceedings Of The 12th International Congress Of Endocrinology. Bologna: Medimond Publishing Co, p. 913-917, 2004.
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/45126
dc.identifier.wosWOS:000227355300155
dc.language.isoeng
dc.publisherMedimond Publishing Co
dc.relation.ispartofProceedings Of The 12th International Congress Of Endocrinology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titleDecreased GH secretion and enhanced ACTH and cortisol release after ghrelin administration in Cushing's disease: comparison with GHRP-6en
dc.typeinfo:eu-repo/semantics/conferenceObject
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