Infection Strategies of Intestinal Parasite Pathogens and Host Cell Responses

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dc.citation.volume7
dc.contributor.authorDi Genova, Bruno M. [UNIFESP]
dc.contributor.authorTonelli, Renata R. [UNIFESP]
dc.coverageLausanne
dc.date.accessioned2020-08-21T16:59:55Z
dc.date.available2020-08-21T16:59:55Z
dc.date.issued2016
dc.description.abstractGiardia lamblia, Cryptosporidium sp., and Entamoeba histolytica are important pathogenic intestinal parasites and are amongst the leading causes worldwide of diarrheal illness in humans. Diseases caused by these organisms, giardiasis, cryptosporidiosis, and amoebiasis, respectively, are characterized by self -limited diarrhea but can evolve to long-term complications. The cellular and molecular mechanisms underlying the pathogenesis of diarrhea associated with these three pathogens are being unraveled, with knowledge of both the strategies explored by the parasites to establish infection and the methods evolved by hosts to avoid it. Special attention is being given to molecules participating in parasite host interaction and in the mechanisms implicated in the diseases' pathophysiologic processes. This review focuses on cell mechanisms that are modulated during infection, including gene transcription, cytoskeleton rearrangements, signal transduction pathways, and cell death.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Microbiol & Imunol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Dept Ciencias Biol, Diadema, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Microbiol & Imunol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Dept Ciencias Biol, Diadema, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: RT 2010/15042-2
dc.description.sponsorshipIDFAPESP: BDG 2013/04272-5
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fmicb.2016.00256
dc.identifier.citationFrontiers In Microbiology. Lausanne, v. 7, p. -, 2016.
dc.identifier.doi10.3389/fmicb.2016.00256
dc.identifier.fileWOS000371213300001.pdf
dc.identifier.issn1664-302X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57802
dc.identifier.wosWOS:000371213300001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Microbiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectprotozoan parasitesen
dc.subjectintestinal infectionen
dc.subjectdiarrheaen
dc.subjectgastrointestinal tracten
dc.subjectintestinal epithelial barrieren
dc.subjectparasite-host interactionen
dc.titleInfection Strategies of Intestinal Parasite Pathogens and Host Cell Responsesen
dc.typeinfo:eu-repo/semantics/article
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