IgG Avidity Test in Congenital Toxoplasmosis Diagnoses in Newborns

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dc.citation.issue2
dc.citation.volume6
dc.contributor.authorFonseca, Zulmirene Cardoso
dc.contributor.authorXavier Rodrigues, Isolina Maria
dc.contributor.authorCruz e Melo, Natalia [UNIFESP]
dc.contributor.authorAvelar, Juliana Boaventura
dc.contributor.authorCastro, Ana Maria
dc.contributor.authorAvelino, Mariza Martins
dc.coverageBasel
dc.date.accessioned2020-07-13T11:52:59Z
dc.date.available2020-07-13T11:52:59Z
dc.date.issued2017
dc.description.abstractThe goal of this study was to investigate the importance of IgG avidity testing in newborns (NBs) diagnosed with early congenital toxoplasmosis. We collected samples from 88 puerperae infected by Toxoplasma gondii (T. gondii) and their NBs (48 acutely-infected puerperae (AIP) and 40 chronically-infected puerperae (CIP)), from two public maternity hospitals in Goiania city, Goias, Brazil, from 2010 to 2015. Specific anti-T. gondii IgM and IgG serum levels and IgG avidity tests were evaluated using chemiluminescence. Congenital toxoplasmosis was observed in 66.66% (n = 32) of NBs with AIP, 94.1% presenting low avidity (LA) and 51.61% presenting high avidity (HA) test results. The IgG and IgM levels of NBs with LA and their puerperae were higher in comparison with HA NBs and puerperae (p = 0.0001). The avidity tests showed 100% specificity and 50% sensitivity (p = 0.0001). NBs with LA had a 15-fold increased risk of developing congenital toxoplasmosis in comparison with HA NBs. The IgG avidity test could be used to assist in early congenital toxoplasmosis diagnoses in NBs and LA, identifying a greater probability of vertical transmission.en
dc.description.affiliationFed Univ Goias UFG, Dept Gynecol & Obstet, Fac Med, BR-74045155 Goiania, Go, Brazil
dc.description.affiliationUniv Fed Goias, Lab Immunol Clin Hosp, BR-74605020 Goiania, Go, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Gynecol, Fac Med, BR-04039032 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Goias, Dept Microbiol Immunol Parasitol & Pathol, Inst Trop Pathol & Publ Hlth, BR-74605450 Goiania, Go, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Gynecol, Fac Med, BR-04039032 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipMunicipal Health Secretariat of Goiania
dc.description.sponsorshipResearch Foundation of the State of Goias, Abbott
dc.description.sponsorshipkits for the negative controls
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3390/pathogens6020026
dc.identifier.citationPathogens. Basel, v. 6, n. 2, p. -, 2017.
dc.identifier.doi10.3390/pathogens6020026
dc.identifier.fileWOS000404553800013.pdf
dc.identifier.issn2076-0817
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54335
dc.identifier.wosWOS:000404553800013
dc.language.isoeng
dc.publisherMdpi Ag
dc.relation.ispartofPathogens
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcongenital toxoplasmosisen
dc.subjectIgG avidityen
dc.subjectdiagnosesen
dc.subjectnewbornsen
dc.subjectpuerperaeen
dc.titleIgG Avidity Test in Congenital Toxoplasmosis Diagnoses in Newbornsen
dc.typeinfo:eu-repo/semantics/article
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