Allergic and immunologic parameters in patients with Fanconi's anemia

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dc.contributor.authorRoxo, P.
dc.contributor.authorArruda, L. K.
dc.contributor.authorNagao-Dias, Aparecida Tiemi [UNIFESP]
dc.contributor.authorCarneiro-Sampaio, MMS
dc.contributor.authorFerriani, VPL
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T12:31:27Z
dc.date.available2016-01-24T12:31:27Z
dc.date.issued2001-08-01
dc.description.abstractBackground: Fanconi's anemia (FA) is a rare recessive chromosomal instability disorder, characterized by progressive bone marrow failure and congenital defects. Patients with FA present with recurrent infections, particularly those of the respiratory tract. Objective: the aim of the present study was to evaluate whether patients with FA have altered antibody-mediated immune responses. Methods: A group of 12 patients with FA, 5-32 years old (6 males) was studied. Serum levels of IgG, IgM, IgA and IgG subclasses, isohemagglutinin titers and specific IgG antibodies to poliovirus and measles were determined using standard methods. Immediate skin tests to common inhalant allergens were performed, and total and specific serum IgE was quantitated using a fluoroenzymatic assay (Uni-CAP, Pharmacia). Antipneumococcal antibodies were measured by ELISA before and 4-8 weeks after immunization with pneumococcal vaccine (Pneumo 23, Pasteur Merieux Connaught). Responses to serotypes 1, 3, 5, 6B, 9V and 14, which are the most prevalent in our country, were studied. Results: Ten patients had elevated IgE levels in sera, and 7 of them had detectable specific IgE and positive immediate skin tests. An inadequate response to pneumococcal vaccination was found in 2 of the 12 patients. Isohemagglutinin titers and levels of IgG, IgM, IgA and IgG subclasses and antipoliovirus and antimeasles antibodies were within the normal limits for age in all patients. Two patients had undetectable IgG4 levels (below 5 mg/dl). Conclusions: the results indicate that a proportion of patients with FA (2/12) in our study had inadequate responses to pneumococcal vaccination. No other significant abnormalities of the immune system were found in these patients. Copyright (C) 2001 S. Karger AG, Basel.en
dc.description.affiliationUniv São Paulo, Sch Med, Dept Pediat, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Dept Cell & Mol Biol, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Ciencias Biomed, Dept Immunol, BR-05508 São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP, EPM
dc.description.sourceWeb of Science
dc.format.extent349-355
dc.identifierhttp://dx.doi.org/10.1159/000053837
dc.identifier.citationInternational Archives of Allergy and Immunology. Basel: Karger, v. 125, n. 4, p. 349-355, 2001.
dc.identifier.doi10.1159/000053837
dc.identifier.issn1018-2438
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26608
dc.identifier.wosWOS:000171176700011
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofInternational Archives of Allergy and Immunology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.karger.com/Services/RightsPermissions
dc.subjectFanconi's anemiaen
dc.subjectpneumococcal polysaccharide vaccine immunoglobulin Een
dc.subjectantibodyen
dc.subjectinfectionsen
dc.titleAllergic and immunologic parameters in patients with Fanconi's anemiaen
dc.typeinfo:eu-repo/semantics/article
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