Inter-relation between brain-derived neurotrophic factor and antioxidant enzymes in bipolar disorder

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dc.contributor.authorMansur, Rodrigo B. [UNIFESP]
dc.contributor.authorSantos, Camila M. [UNIFESP]
dc.contributor.authorRizzo, Lucas B. [UNIFESP]
dc.contributor.authorCunha, Graccielle R. [UNIFESP]
dc.contributor.authorAsevedo, Elson [UNIFESP]
dc.contributor.authorNoto, Mariane N. [UNIFESP]
dc.contributor.authorPedrini, Mariana [UNIFESP]
dc.contributor.authorZeni, Maiara [UNIFESP]
dc.contributor.authorCordeiro, Quirino [UNIFESP]
dc.contributor.authorMcIntyre, Roger S. [UNIFESP]
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.date.accessioned2019-07-22T15:46:57Z
dc.date.available2019-07-22T15:46:57Z
dc.date.issued2016
dc.description.abstractObjectives: Accumulating evidence indicates that oxidative stress and neurotrophins have a bidirectional relationship. In this post hoc, exploratory analysis, we investigated the association between plasma brain-derived neurotrophic factor (BDNF) levels and activities of the antioxidant enzymes glutathione peroxidase (GPx) and superoxide dismutase (SOD) in individuals with bipolar disorder (BD) and healthy controls. Methods: We measured plasma levels of BDNF and activities of GPx and SOD in individuals with BD (n=59) and healthy controls (n=26). Information related to current and past psychiatric/medical history, as well as to metabolic comorbidities, was also reported. Results: There were negative correlations between BDNF, GPx (r=-.449, P=.001) and GPx/SOD ratio (r=-.503, P<.001), and a positive correlation between BDNF and SOD (r=.254, P=.020). There was a moderating effect of body mass index (BMI) on the association between BDNF and GPx/SOD rate ratio [(RR)=1.002, P=.034]en
dc.description.abstractinteractions between impaired glucose metabolism (IGM), GPx (RR=1.016, P=.033), and GPx/SOD ratio (RR=1.026, P=.002) were also observed. These results were significant in models that included age, gender, alcohol, tobacco and medication use. Conclusions: There was a robust and independent correlation between peripheral BDNF and antioxidant enzyme activities in individuals with BD, which was moderated by metabolic comorbidities. These results reinforce the concept that these systems are associated and further extend knowledge of the putative effect of metabolic comorbidities in the pathophysiological substrates of BD.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Psychiat, Res Grp Behav Neurosci Bipolar Disorder GP TB, Sao Paulo, Brazil
dc.description.affiliationUniv Toronto, Univ Hlth Network, MDPU, 399 Bathurst St,MP 9-325, Toronto, ON M5T 2S8, Canada
dc.description.affiliationUniv Tubingen, Clin Psychiat & Psychotherapy, Dept Psychiat, Tubingen, Germany
dc.description.affiliationVila Maria Outpatient Clin, Sao Paulo, Brazil
dc.description.affiliationISCMSP, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Psychiat, Res Grp Behav Neurosci Bipolar Disorder GP TB, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent433-439
dc.identifierhttp://dx.doi.org/10.1111/bdi.12418
dc.identifier.citationBipolar Disorders. Hoboken, v. 18, n. 5, p. 433-439, 2016.
dc.identifier.doi10.1111/bdi.12418
dc.identifier.issn1398-5647
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51202
dc.identifier.wosWOS:000388307900005
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectbipolar disorderen
dc.subjectbody mass indexen
dc.subjectbrain-derived neurotrophic factoren
dc.subjectdiabetesen
dc.subjectoxidative stressen
dc.titleInter-relation between brain-derived neurotrophic factor and antioxidant enzymes in bipolar disorderen
dc.typeinfo:eu-repo/semantics/article
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