Heme oxygenase-1 (HO-1), a protective gene that prevents chronic graft dysfunction

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dc.contributor.authorCamara, NOS
dc.contributor.authorSoares, M. P.
dc.contributor.institutionGulbenkian Inst Sci
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:37:40Z
dc.date.available2016-01-24T12:37:40Z
dc.date.issued2005-02-15
dc.description.abstractHeme oxygenase-1 (HO-1) is a stress-responsive enzyme that acts during inflammatory reactions as the rate-limiting step in the catabolism of heme, yielding equimolar amounts of iron (Fe), biliverdin, and the gas carbon monoxide (CO) [1]. Expression of HO-1 regulates inflammatory and immune responses, such as those involved in the rejection of transplanted organs. We will discuss here accumulating evidence supporting the notion that expression of HO-1 in a transplanted organ can prevent its rejection. We will argue that the protective effects exerted by HO-1 are mediated to a large extent by the end products that it generates via the catabolism of heme. Better knowledge of how to enhance these protective effects is likely to help create new therapeutic strategies to improve the outcome of transplanted organs. (C) 2004 Elsevier Inc. All rights reserved.en
dc.description.affiliationGulbenkian Inst Sci, Inflammat Lab, P-62780 Oeiras, Portugal
dc.description.affiliationUNIFESP, Div Nephrol, Clin & Expt Immunol Lab, São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP, Div Nephrol, Clin & Expt Immunol Lab, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent426-435
dc.identifierhttp://dx.doi.org/10.1016/j.freeradbiomed.2004.11.019
dc.identifier.citationFree Radical Biology and Medicine. Oxford: Pergamon-Elsevier B.V., v. 38, n. 4, p. 426-435, 2005.
dc.identifier.doi10.1016/j.freeradbiomed.2004.11.019
dc.identifier.issn0891-5849
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28155
dc.identifier.wosWOS:000226922400003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFree Radical Biology and Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectfree radicalsen
dc.subjectheme oxygenase-1en
dc.subjectcarbon monoxideen
dc.subjecttransplantationen
dc.subjectprotective geneen
dc.subjectinflarmationen
dc.subjectendothelialen
dc.titleHeme oxygenase-1 (HO-1), a protective gene that prevents chronic graft dysfunctionen
dc.typeinfo:eu-repo/semantics/article
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