Are adverse effects of antiepileptic drugs different in symptomatic partial and idiopathic generalized epilepsies? the Portuguese-Brazilian validation of the Liverpool Adverse Events Profile

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dc.contributor.authorMartins, Heloise Helena [UNIFESP]
dc.contributor.authorAlonso, Neide Barreira [UNIFESP]
dc.contributor.authorVidal-Dourado, Marcos [UNIFESP]
dc.contributor.authorCarbonel, Thiago Delfino [UNIFESP]
dc.contributor.authorAraujo Filho, Gerardo Maria de [UNIFESP]
dc.contributor.authorCaboclo, Luís Otávio Sales Ferreira [UNIFESP]
dc.contributor.authorYacubian, Elza Márcia Targas [UNIFESP]
dc.contributor.authorGuilhoto, Laura Maria de Figueiredo Ferreira [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:17:20Z
dc.date.available2016-01-24T14:17:20Z
dc.date.issued2011-11-01
dc.description.abstractWe report the results of administration of the Portuguese-Brazilian translation of the Liverpool Adverse Events Profile (LAEP) to 100 patients (mean age = 34.5, SD = 12.12; 56 females), 61 with symptomatic partial epilepsy (SPE) and 39 with idiopathic generalized epilepsy (ICE) (ILAE, 1989) who were on a stable antiepileptic drug (AED) regimen and being treated in a Brazilian tertiary epilepsy center. Carbamazepine was the most commonly used AED (43.0%), followed by valproic acid (32.0%). Two or more AEDs were used by 69.0% of patients. the mean LAEP score (19 questions) was 37.6 (SD = 13.35). the most common adverse effects were sleepiness (35.0%), memory problems (35.0%), and difficulty in concentrating (25.0%). Higher LAEP scores were associated with polytherapy with three or more AEDs (P=0.005), female gender (P<0.001), older age (P<0.001), and uncontrolled seizures (P = 0.045). the intraclass coefficient (test-retest reliability) for LAEP overall score was 0.848 (95% CI = 0.782-0.895), with a range from 0.370 (unsteadiness) to 0.750 (memory problems). Cronbach's alpha coefficient (internal consistency) was 0.903. the LAEP was highly correlated with Quality of Life in Epilepsy-31 inventory (r = -0.804, P>0.001) and Hospital Anxiety and Depression Scale (Depression: r = 0.637, P<0.001; Anxiety: r = 0.621, P<0.001) dimensions. LAEP overall scores were similar in people with SPE and IGE and were not helpful in differentiating adverse effects in these two groups. Clinical variables that influenced global LAEP were seizure frequency (P = 0.050) and generalized tonic-clonic seizures in the last month (P = 0.031) in the ICE group, and polytherapy with three or more AEDs (P = 0.003 and P = 0.003) in both ICE and SPE groups. (C) 2011 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent511-517
dc.identifierhttp://dx.doi.org/10.1016/j.yebeh.2011.08.005
dc.identifier.citationEpilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 22, n. 3, p. 511-517, 2011.
dc.identifier.doi10.1016/j.yebeh.2011.08.005
dc.identifier.fileWOS000296826700017.pdf
dc.identifier.issn1525-5050
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34163
dc.identifier.wosWOS:000296826700017
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEpilepsy & Behavior
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectLiverpool Adverse Events Profileen
dc.subjectAntiepileptic drugsen
dc.subjectEpilepsyen
dc.subjectAdverse effectsen
dc.subjectSymptomatic partial epilepsyen
dc.subjectIdiopathic generalized epilepsyen
dc.subjectValidationen
dc.titleAre adverse effects of antiepileptic drugs different in symptomatic partial and idiopathic generalized epilepsies? the Portuguese-Brazilian validation of the Liverpool Adverse Events Profileen
dc.typeinfo:eu-repo/semantics/article
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