Incorporation of bacitracin in Langmuir films of phospholipids at the air-water interface

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dc.citation.volume622
dc.contributor.authorRodrigues, Jefferson Carnevalle [UNIFESP]
dc.contributor.authorCaseli, Luciano [UNIFESP]
dc.coverageLausanne
dc.date.accessioned2020-07-17T14:03:12Z
dc.date.available2020-07-17T14:03:12Z
dc.date.issued2017
dc.description.abstractProperties of microbicide drugs are believed to be associated to their interactions with biointerfaces such as cell membranes, encouraging research on the identification of membrane sites capable of drug binding. In this study, we investigated the interaction of bacitracin, a known antibiotic peptide, with cell membrane models represented by Langmuir monolayers of selected phospholipids. It is shown that even small amounts of bacitracin affect the surface pressure-area isotherms, as well as the vibrational spectra and the morphology of phospholipid monolayers, which points to a specific interaction for each phospholipid. Such effects depend on the chemical nature of the monolayer-forming molecules, with the drug activity being distinctive for dipalmitoyl-sn-glycero-3-phospho-L-serine sodium salt in contrast to what was observed for 1,2-dipalmitoyl-sn-glycero-3phospho-L-choline and 1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) sodium salt. As a result, the phospholipid composition of the monolayer modulates the interaction with the peptide, which may have important implications in understanding how the drug acts on specific sites of cell membranes. (C) 2016 Elsevier B.V. All rights reserved.en
dc.description.affiliationFed Univ Sao Paulo Unifesp, Inst Environm Chem & Pharmaceut Sci, Rua Sao Nicolau 210, Diadema, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo Unifesp, Inst Environm Chem & Pharmaceut Sci, Rua Sao Nicolau 210, Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFAPESP
dc.description.sponsorshipCNPq
dc.description.sponsorshiprede nBionet: Films and Sensors (CAPES)
dc.description.sponsorshipINEO (INCT-CNPq)
dc.description.sponsorshipIDFAPESP: 2015/23446-0
dc.description.sponsorshipIDCNPq: 470890/2012-6
dc.format.extent95-103
dc.identifierhttp://dx.doi.org/10.1016/j.tsf.2016.12.019
dc.identifier.citationThin Solid Films. Lausanne, v. 622, p. 95-103, 2017.
dc.identifier.doi10.1016/j.tsf.2016.12.019
dc.identifier.issn0040-6090
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55228
dc.identifier.wosWOS:000393010200015
dc.language.isoeng
dc.publisherElsevier Science Sa
dc.relation.ispartofThin Solid Films
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBacitracinen
dc.subjectLangmuir monolayersen
dc.subjectLangmuir-Blodgetten
dc.subjectBiomembrane modelsen
dc.subjectTensiometryen
dc.titleIncorporation of bacitracin in Langmuir films of phospholipids at the air-water interfaceen
dc.typeinfo:eu-repo/semantics/article
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