The imbalance of sex-hormones related to depressive symptoms in obese men

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dc.contributor.authorMonteagudo, Patrícia Teófilo [UNIFESP]
dc.contributor.authorFalcão, Adriana Andrade [UNIFESP]
dc.contributor.authorVerreschi, Ieda Therezinha do Nascimento [UNIFESP]
dc.contributor.authorZanella, Maria-Teresa [UNIFESP]
dc.date.accessioned2019-01-21T10:29:23Z
dc.date.available2019-01-21T10:29:23Z
dc.date.issued2016
dc.description.abstractObese men may present hypogonadothrofic hypogonadism, mainly related to higher insulinemia and aromatase activity. Our objectives were to evaluate the relationship of sex-hormones profiles and frequency of depressive symptoms in 43 obese men, in a cross-sectional study. They had 19-60 years, and body mass index 30-50kg/m(2). LH, total and free testosterone (TT and FT), estradiol (E-2), sex hormone binding globulin, estradiol/total testosterone ratio (E-2/T) were analyzed. Depressive symptoms were evaluated by beck depression inventory (BDI), and significant depression was considered if BDI16.Thirty-four (80%) presented low TT levels, but only 4 (14%) had low free testosterone and hypogonadism symptomsen
dc.description.abstract12 of 43 (28%) presented increased E-2. Forty five (56%) presented depressive symptoms, but 16 (28% of the 45) had significant depression. BDI correlated positively with E-2 (r=0.407en
dc.description.abstractp=0.001) and E-2/T (r=0.473en
dc.description.abstractp=0.001), but not TT or FT. Patients with significant depressive showed higher levels of estradiol (136 +/- 48 versus 103 +/- 48pg/ml, p=0.02) and E-2/T (16.0 +/- 9.9 versus 9.8 +/- 4.6en
dc.description.abstractp=0.002) (mean +/- SD).In conclusion, obese men may present relatively excess of estradiol and deficiency in testosterone, leading to an imbalance between these two hormones. The greater this imbalance, the more depressive symptoms had our patients.en
dc.description.affiliationEndocrinology Outpatient Clinic of Kidney and Hypertension Hospital and Endocrinology Division, Escola Paulista de Medicina, Federal University of São Paulo, Rua Leandro Dupret 365, BR-04025011, São Paulo, Brazil
dc.description.affiliationUnifespEndocrinology Outpatient Clinic of Kidney and Hypertension Hospital and Endocrinology Division, Escola Paulista de Medicina, Federal University of São Paulo, Rua Leandro Dupret 365, BR-04025011, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipBrazilian "National Council for ScientificResearch" (CNPq)
dc.format.extent20-26
dc.identifierhttps://doi.org/10.3109/13685538.2015.1084500
dc.identifier.citationAging Male. Abingdon, v. 19, n. 1, p. 20-26, 2016.
dc.identifier.doi10.3109/13685538.2015.1084500
dc.identifier.issn1368-5538
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49199
dc.identifier.wosWOS:000372177200004
dc.language.isoeng
dc.publisherUniv Fed Rio De Janeiro, Fac Letras
dc.relation.ispartofAging Male
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBeck Inventoryen
dc.subjectDepressive Symptomsen
dc.subjectHypogonatropic Hypogonadismen
dc.subjectMale ObesityTestosterone-Replacement Therapyen
dc.subjectAndrogen Receptor Polymorphismen
dc.subjectOlder Menen
dc.subjectHypogonadotropic Hypogonadismen
dc.subjectMood Disordersen
dc.subjectElderly-Menen
dc.subjectInsulinen
dc.subjectAnxietyen
dc.subjectSerumen
dc.subjectAssociationen
dc.titleThe imbalance of sex-hormones related to depressive symptoms in obese menen
dc.typeinfo:eu-repo/semantics/article
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