Low-level laser therapy in the prevention and treatment of chemotherapy-induced oral mucositis in young patients

Página do item simplificado
dc.contributor.authorFracher Abramoff, Meire Maman
dc.contributor.authorFontana Lopes, Nilza Nelly [UNIFESP]
dc.contributor.authorLopes, Luciana Almeida
dc.contributor.authorDib, Luciano Lauria
dc.contributor.authorGuilherme, Arnaldo
dc.contributor.authorCaran, Eliana Monteiro [UNIFESP]
dc.contributor.authorBarreto, Adriana Delboni
dc.contributor.authorMartinho Lee, Maria Lucia [UNIFESP]
dc.contributor.authorPetrilli, Antonio Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionNUPEN
dc.date.accessioned2016-01-24T13:51:36Z
dc.date.available2016-01-24T13:51:36Z
dc.date.issued2008-08-01
dc.description.abstractObjective: A pilot clinical study was conducted to evaluate the efficacy and feasibility of low-level laser therapy (LLLT) in the prevention and treatment of chemotherapy (CT)-induced oral mucositis (OM) in young patients.Background Data: Besides compromising the patient's nutrition and well-being, oral mucositis represents a portal of entry into the body for microorganisms present in the mouth, which may lead to sepsis if there is hematological involvement. Oncologic treatment tolerance decreases and systemic complications may arise that interfere with the success of cancer treatment. LLLT appears to be an interesting alternative to other approaches to treating OM, due to its trophic, anti-inflammatory, and analgesic properties.Materials and Methods: Patients undergoing chemotherapy (22 cycles) without mucositis were randomized into a group receiving prophylactic laser-irradiation (group 1), and a group receiving placebo light treatment (group 2). Patients who had already presented with mucositis were placed in a group receiving irradiation for therapeutic purposes (group 3, with 10 cycles of CT). Serum granulocyte levels were taken and compared to the progression of mucositis.Results: in group 1, most patients (73%) presented with mucositis of grade 0 (p = 0.03 when compared with the placebo group), and 18% presented with grade 1. in group 2, 27% had no OM and did not require therapy. in group 3, the patients had marked pain relief (as assessed by a visual analogue scale), and a decrease in the severity of OM, even when they had severe granulocytopenia.Conclusion: the ease of use of LLLT, high patient acceptance, and the positive results achieved, make this therapy feasible for the prevention and treatment of OM in young patients.en
dc.description.affiliationUniversidade Federal de São Paulo, Inst IOP GRAACC, São Paulo, Brazil
dc.description.affiliationNUPEN, Res & Educ Ctr Photo Therapy Hlth Sci, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, GRAACC, Inst Pediat, IOP, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Inst IOP GRAACC, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, GRAACC, Inst Pediat, IOP, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent393-400
dc.identifierhttp://dx.doi.org/10.1089/pho.2007.2144
dc.identifier.citationPhotomedicine and Laser Surgery. New Rochelle: Mary Ann Liebert Inc, v. 26, n. 4, p. 393-400, 2008.
dc.identifier.doi10.1089/pho.2007.2144
dc.identifier.issn1549-5418
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30833
dc.identifier.wosWOS:000259126200018
dc.language.isoeng
dc.publisherMary Ann Liebert Inc
dc.relation.ispartofPhotomedicine and Laser Surgery
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titleLow-level laser therapy in the prevention and treatment of chemotherapy-induced oral mucositis in young patientsen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos