Insulin resistance and not steatosis is associated with modifications in oxidative stress markers in chronic hepatitis C, non-3 genotype

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dc.contributor.authorOliveira, Ana C. [UNIFESP]
dc.contributor.authorParise, Edison Roberto [UNIFESP]
dc.contributor.authorCatarino, Regina M. [UNIFESP]
dc.contributor.authorLanzoni, Valeria Pereira [UNIFESP]
dc.contributor.authorLeite-Mór, Marilisa Moraes Barros [UNIFESP]
dc.contributor.authorSimon, Karin Argenti [UNIFESP]
dc.contributor.authorJunqueira, Virginia B. C. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:52:10Z
dc.date.available2016-01-24T13:52:10Z
dc.date.issued2009-01-01
dc.description.abstractBackground: Modifications of oxidative stress are reported in hepatitis C. the relationship between insulin resistance (IR), steatosis and oxidative stress is not established. Materials and methods: One hundred and eighty-seven HCV-RNA patients were assessed by determination of biochemical, metabolic and viral features, HOMA-IR and morphological alterations. in the 52-non-3 genotypes sub-group and 35 healthy individuals, thiobarbituric acid (TBARS), total glutathione (total-GSH), vitamins C and E, lycopene, beta-carotene, glutathione peroxidase (GPx), catalase and superoxide dismutase were determined. Results: in non-3 genotype patients, steatosis was associated with higher values of BMI, HOMA-IR and triglycerides. in the 52-HCV sub-group, values of TBARS, GPx and total-GSH differ from the control group. Despite these, differences could not be observed according to the presence of steatosis, patients with IR presented significant differences regarding total-GSH (p = 0.019), beta-carotene (p = 0.006), lycopene (p = 0.005) and GPx (p = 0.009). Conclusion: in non-3 genotype HCV carries, IR, and not steatosis, is associated with modifications in serum levels of oxidative stress.en
dc.description.affiliationUniversidade Federal de São Paulo, Div Gastroenterol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biol Sci, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Gastroenterol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biol Sci, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 02/05260-6
dc.format.extent1187-1194
dc.identifierhttp://dx.doi.org/10.3109/10715760903247249
dc.identifier.citationFree Radical Research. Abingdon: Taylor & Francis Ltd, v. 43, n. 12, p. 1187-1194, 2009.
dc.identifier.doi10.3109/10715760903247249
dc.identifier.issn1071-5762
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31239
dc.identifier.wosWOS:000272753100005
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofFree Radical Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.subjectInsulin resistanceen
dc.subjectchronic hepatitis Cen
dc.subjecthepatic steatosisen
dc.subjectoxidative stress markersen
dc.subjectfibrosisen
dc.titleInsulin resistance and not steatosis is associated with modifications in oxidative stress markers in chronic hepatitis C, non-3 genotypeen
dc.typeinfo:eu-repo/semantics/article
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