Transport of mucoid mucus in healthy individuals and patients with chronic obstructive pulmonary disease and bronchiectasis

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dc.contributor.authorAfonso, Juliana Lima
dc.contributor.authorTambascio, Joana
dc.contributor.authorSouza, Hugo Celso Dutra de
dc.contributor.authorJardim, José Roberto [UNIFESP]
dc.contributor.authorMartinez, José Antônio Baddini
dc.contributor.authorGastaldi, Ada Clarice [UNIFESP]
dc.contributor.institutionCtr Univ Tridngulo
dc.contributor.institutionFac Med Ribeirao Preto
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:34:18Z
dc.date.available2016-01-24T14:34:18Z
dc.date.issued2013-09-01
dc.description.abstractObjective: To characterise and compare the in vitro transport properties of respiratory mucoid secretion in individuals with no lung disease and in stable patients with chronic obstructive pulmonary disease (COPD) and bronchiectasis.Methodology: Samples of mucus were collected, from 21 volunteers presenting no lung disease who had undergone surgery, from 10 patients presenting chronic COPD, and from 16 patients with bronchiectasis. Mucociliary transport (MCT), transport by cough (SCM), and contact angle (CAM) were evaluated.Results: MCT was found to be greater in healthy individuals (1.0 +/- 0.19) than in COPD (0.91 +/- 0.17) and bronchiectasis (0.76 +/- 0.23) patients (p < 0.05), whereas SCM was greater in COPD patients (16.31 +/- 7.35 cm) than in patients with bronchiectasis (12.16 +/- 6.64 cm) and healthy individuals (10.50 +/- 25.8 cm) (p < 0.05). No significant differences were observed between the groups regarding CAM.Conclusion: Mucus from healthy individuals allows better mucociliary transport compared to that from patients with lung diseases. However, the mucus from COPD patients allows a better transport by coughing, demonstrating that these individuals have adapted to a defence mechanism compared to patients with bronchiectasis, who have impairment in their ciliary and cough transport mechanisms. (c) 2012 Sociedade Portuguesa de Pneumologia. Published by Elsevier Espana, S.L. All rights reserved.en
dc.description.affiliationCtr Univ Tridngulo, Dept Fisioterapia, Uberlandia, MG, Brazil
dc.description.affiliationFac Med Ribeirao Preto, Dept Fisioterapia, Ribeirao Preto, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pneumol, São Paulo, Brazil
dc.description.affiliationFac Med Ribeirao Preto, Dept Pneumol, Ribeirao Preto, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pneumol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent211-216
dc.identifierhttp://dx.doi.org/10.1016/j.rppneu.2013.03.002
dc.identifier.citationRevista Portuguesa de Pneumologia. Barcelona: Elsevier Doyma Sl, v. 19, n. 5, p. 211-216, 2013.
dc.identifier.doi10.1016/j.rppneu.2013.03.002
dc.identifier.fileWOS000325382700006.pdf
dc.identifier.issn0873-2159
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36665
dc.identifier.wosWOS:000325382700006
dc.language.isopor
dc.publisherElsevier B.V.
dc.relation.ispartofRevista Portuguesa de Pneumologia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectCOPDen
dc.subjectBronchiectasisen
dc.subjectRespiratory mucusen
dc.subjectMucociliary clearanceen
dc.titleTransport of mucoid mucus in healthy individuals and patients with chronic obstructive pulmonary disease and bronchiectasisen
dc.typeinfo:eu-repo/semantics/article
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