Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells

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dc.contributor.authorFurlanetto, Tania Weber [UNIFESP]
dc.contributor.authorNunes Jr., R.b.
dc.contributor.authorSopelsa, A.m.i.
dc.contributor.authorMaciel, Rui Monteiro de Barros [UNIFESP]
dc.contributor.institutionUniversidade Federal do Rio Grande do Sul Hospital de Clínicas de Porto Alegre Divisão de Medicina Interna
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:25:10Z
dc.date.available2015-06-14T13:25:10Z
dc.date.issued2001-02-01
dc.description.abstractEstradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently reported. The aim of the present investigation was to study the effect of estradiol on iodide uptake by thyroid follicular cells, using FRTL-5 cells as a model. Estradiol decreased basal iodide uptake by FRTL-5 cells from control levels of 2.490 ± 0.370 to 2.085 ± 0.364 pmol I-/µg DNA at 1 ng/ml (P<0.02), to 1.970 ± 0.302 pmol I-/µg DNA at 10 ng/ml (P<0.003), and to 2.038 ± 0.389 pmol I-/µg DNA at 100 ng/ml (P<0.02). In addition, 4 ng/ml estradiol decreased iodide uptake induced by 0.02 mIU/ml thyrotropin from 8.678 ± 0.408 to 7.312 ± 0.506 pmol I-/µg DNA (P<0.02). A decrease in iodide uptake by thyroid cells caused by estradiol has not been described previously and may have a role in goiter pathogenesis.en
dc.description.affiliationUniversidade Federal do Rio Grande do Sul Hospital de Clínicas de Porto Alegre Divisão de Medicina Interna
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Medicina Divisão de Endocrinologia
dc.description.affiliationUnifespUNIFESP, Depto. de Medicina Divisão de Endocrinologia
dc.description.sourceSciELO
dc.format.extent259-263
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2001000200015
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 2, p. 259-263, 2001.
dc.identifier.doi10.1590/S0100-879X2001000200015
dc.identifier.fileS0100-879X2001000200015.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2001000200015
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/1100
dc.identifier.wosWOS:000167337600015
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectiodide uptakeen
dc.subjectestradiolen
dc.subjectthyroiden
dc.subjectfollicular cellsen
dc.titleEstradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cellsen
dc.typeinfo:eu-repo/semantics/article
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