Bone mineral density of the lumbar spine in children and adolescents with celiac disease on a gluten-free diet in São Paulo, Brazil

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dc.contributor.authorSdepanian, Vera Lucia [UNIFESP]
dc.contributor.authorCarvalho, Cecília Noronha de Miranda [UNIFESP]
dc.contributor.authorMorais, Mauro Batista de [UNIFESP]
dc.contributor.authorColugnati, Fernando Antonio Basile [UNIFESP]
dc.contributor.authorFagundes Neto, Ulysses [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:34:06Z
dc.date.available2016-01-24T12:34:06Z
dc.date.issued2003-11-01
dc.description.abstractBackground: To compare bone mineral density (BMD) in children and adolescents with celiac disease (CD) and control subjects and to evaluate diet adequacy and calcium metabolism in patients with CD.Methods: Thirty patients with asymptomatic CD (17 children, 13 adolescents). on a gluten-free diet, and 23 healthy subjects were studied. BMD of the lumbar spine (dual energy x-ray absorptiometry) was performed on all patients and control subjects. in patients. food diaries for nine nonconsecutive days were obtained and analyzed. in patients, laboratory tests pertaining to calcium balance were obtained.Results: the mean weight and height of the adolescents with CD Were lower than those of control subjects (weight: 45.8 +/- 10.5 kg v 55.3 +/- 10.5 kg, P = 0.037; height: 153.0 +/- 11.0 cm v 167 +/- 12.0 cm. P = 0.007). the mean BMD in adolescents With CD was significantly lower than that of the control subjects (0.917 +/- 0.116 g/cm(2) v 1.060 +/- 0.158 g/cm(2), P = 0.015), whereas no significant difference was found between children with CD and control subjects (P = 0.595). A multiple-regression model shows that increases in BMD relative to height were lower in adolescents with CD than in control subjects. the proportion of adolescents who had started a gluten-free diet after 2 years of age was higher than that of children with CD (P < 0.001). High percentages of magnesium, calcium, and phosphorous deficiencies were present in CD patients' diets. the serum levels of ionized and total calcium and parathormone were normal.Conclusions: the BMD of adolescents with CD was lower than that of the control subjects, whereas no difference was found between the BMD of children with CD and that of control subjects.en
dc.description.affiliationUniversidade Federal de São Paulo, Div Pediat Gastroenterol, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Pediat Gastroenterol, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent571-576
dc.identifierhttp://dx.doi.org/10.1097/00005176-200311000-00013
dc.identifier.citationJournal of Pediatric Gastroenterology and Nutrition. Philadelphia: Lippincott Williams & Wilkins, v. 37, n. 5, p. 571-576, 2003.
dc.identifier.doi10.1097/00005176-200311000-00013
dc.identifier.issn0277-2116
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27455
dc.identifier.wosWOS:000186329000012
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutrition
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectceliac diseaseen
dc.subjectbone mineral densityen
dc.subjectgluten-free dieten
dc.subjectnutritional statusen
dc.subjectChildrenen
dc.subjectadolescentsen
dc.titleBone mineral density of the lumbar spine in children and adolescents with celiac disease on a gluten-free diet in São Paulo, Brazilen
dc.typeinfo:eu-repo/semantics/article
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