Should adolescents with glomerulopathies be treated as children or adults?

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dc.contributor.authorRequiao-Moura, Lucio R. [UNIFESP]
dc.contributor.authorFreitas, Taina Veras de S. [UNIFESP]
dc.contributor.authorFranco, Marcello F. [UNIFESP]
dc.contributor.authorPereira, Aparecido B. [UNIFESP]
dc.contributor.authorMastroianni-Kirsztajn, Gianna [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:49:27Z
dc.date.available2016-01-24T13:49:27Z
dc.date.issued2008-01-01
dc.description.abstractBackground: Glomerular diseases are an important cause of end-stage renal disease, especially among young adults. However, clinical and epidemiological surveys involving adolescent populations are scarce. Aim: To determine the pattern of glomerulopathies (GP) in adolescents submitted to renal biopsy.Methods: A retrospective study of patients' records of the Glomerulopathy Section, UNIFESP (Brazil), was performed.Results: Among 72 adolescents (12-18 years) with GP, 15.6 +/- 1.5 years, 58.3% females, the most frequent clinical manifestation was nephrotic syndrome (NS, 71%) and focal segmental glomerulosclerosis (FSGS) was the main histological pattern (24%), followed by minimal change disease (MCD, 19.5%). After comparing the main causes of NS in adolescents with those of adults, we found no statistically significant differences in clinical presentation or outcome. Renal failure-free survival of 1 and 5 years for all GP corresponded to 87.9 and 73.6%, respectively (88.5 and 76.3% for NS).Conclusions: NS was the main manifestation; FSGS and MCD were the most common histological diagnoses. Our data suggest the GP and particularly the NS pattern in adolescents is similar to that of adults, pointing to the need for an adaptation in diagnostic and treatment protocols for this age group, a pattern which corresponds more closely to that of adults. Copyright (c) 2008 S. Karger AG, Basel.en
dc.description.affiliationUniversidade Federal de São Paulo, Discipline Nefrol, Glomerulopathies & Renal Immunopathol Sect, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Discipline Nefrol, Glomerulopathies & Renal Immunopathol Sect, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extentC161-C167
dc.identifierhttp://dx.doi.org/10.1159/000145460
dc.identifier.citationNephron Clinical Practice. Basel: Karger, v. 109, n. 3, p. C161-C167, 2008.
dc.identifier.doi10.1159/000145460
dc.identifier.issn1660-2110
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30357
dc.identifier.wosWOS:000258726000008
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofNephron Clinical Practice
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.karger.com/Services/RightsPermissions
dc.subjectadolescenten
dc.subjectglomerular diseaseen
dc.subjectglomerulonephritisen
dc.subjectnephrotic syndromeen
dc.subjectepidemiologyen
dc.titleShould adolescents with glomerulopathies be treated as children or adults?en
dc.typeinfo:eu-repo/semantics/article
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