Elastin rs2301995 Polymorphism is not Associated with Polypoidal Choroidal Vasculopathy in Caucasians

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dc.contributor.authorLima, Luiz H. [UNIFESP]
dc.contributor.authorMerriam, Joanna E.
dc.contributor.authorFreund, K. Bailey
dc.contributor.authorBarbazetto, Irene A.
dc.contributor.authorSpaide, Richard F.
dc.contributor.authorYannuzzi, Lawrence A.
dc.contributor.authorAllikmets, Rando
dc.contributor.institutionColumbia Univ
dc.contributor.institutionManhattan Eye Ear & Throat Hosp
dc.contributor.institutionMacula Consultants New York
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:16:52Z
dc.date.available2016-01-24T14:16:52Z
dc.date.issued2011-06-01
dc.description.abstractMethods: Association analysis of allele and genotype frequencies, determined by TaqMan assays, was performed for the rs2301995 haplotype-tagging single nucleotide polymorphism (htSNP) in the ELN locus in fifty-six patients with PCV, 368 patients with advanced age-related macular degeneration (AMD) and 368 age- and ethnically-matched unaffected controls.Results: the ELN rs2301995 SNP was not statistically significantly associated with the PCV phenotype (P == 0.9). the frequency of the minor allele of the rs2301995 SNP was practically identical in the PCV, AMD and control groups (6.3% vs. 5.4% vs. 7.1%).Conclusion: the PCV phenotype in European-American patients is not associated with rs2301995 SNP in the ELN locus.en
dc.description.affiliationColumbia Univ, Eye Inst Res Addit, Dept Pathol & Cell Biol, New York, NY 10032 USA
dc.description.affiliationManhattan Eye Ear & Throat Hosp, LuEsther T Mertz Retina Res Ctr, New York, NY USA
dc.description.affiliationMacula Consultants New York, Vitreous, Retina, New York, NY USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationColumbia Univ, Dept Ophthalmol, New York, NY 10032 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent80-82
dc.identifierhttp://dx.doi.org/10.3109/13816810.2010.544362
dc.identifier.citationOphthalmic Genetics. London: Informa Healthcare, v. 32, n. 2, p. 80-82, 2011.
dc.identifier.doi10.3109/13816810.2010.544362
dc.identifier.issn1381-6810
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33792
dc.identifier.wosWOS:000290488500003
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofOphthalmic Genetics
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.titleElastin rs2301995 Polymorphism is not Associated with Polypoidal Choroidal Vasculopathy in Caucasiansen
dc.typeinfo:eu-repo/semantics/article
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