Expression and Prognostic Relevance of GAGE1 and XAGE1 Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma

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dc.citation.issue10
dc.citation.volume17
dc.contributor.authorKaria, B. T. R. [UNIFESP]
dc.contributor.authorZamuner, F. T. [UNIFESP]
dc.contributor.authorCarlin, V. [UNIFESP]
dc.contributor.authorde Oliveira, C. Z.
dc.contributor.authorCarvalho, A. L.
dc.contributor.authorVettore, A. L. [UNIFESP]
dc.coverageSharjah
dc.date.accessioned2020-07-17T14:03:17Z
dc.date.available2020-07-17T14:03:17Z
dc.date.issued2017
dc.description.abstractBackground: In the last decades, survival rates in head and neck squamous cell carcinoma (HNSCC) have not changed, with a five-year survival of only 50%. Thus, there is a great need for the identification of new molecular targets and development of novel therapeutic strategies. Cancer-testis antigens (CTAs) are expressed in various types of tumor but rarely in healthy normal tissues. Therefore, they appear as ideal targets for immunotherapy approaches, as well as, unique markers for cancer diagnosis/prognosis. Objective: This study evaluated the expression pattern of cancer/testis antigens (CTA) in HNSCC samples and correlated the expression data with the clinicopathological prognostic variables. Methods: An in silico screening was performed using all CTA genes cataloged on the CTDatabase and the expression of the eight CTA genes (ARMC3, DDX53, FTHL17, GAGE1, MAGEA11, SYCE1, TCP11, and XAGE1) was examined in 89 HNSCC and 20 normal mucosa samples using RT-PCR analysis. Results: GAGE1 (48.3%), XAGE1 (40.4%) and MAGEA11 (19.1%) were frequently and specifically expressed in HNSCC samples and 68.5% of the cases expressed at least one of these antigens. Moreover, GAGE1 and XAGE1 mRNA positivity was significantly associated with the presence of metastasis in the lymph nodes (p=0.038 and p=0.023, respectively) and, by multivariate analysis, male gender (p=0.032), advanced clinical stage (p=0.018) and mRNA positivity for GAGE1 (p=0.010) were independent prognostic factors for overall survival. Conclusion: These findings suggest GAGE1 and XAGE1 expressions to be useful as prognostic markers for HNSCC.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Biol Sci, Lab Canc Mol Biol, Diadema, Brazil
dc.description.affiliationPIO XII Fdn, Hosp Canc Barretos, Biostat Dept, Barretos, Brazil
dc.description.affiliationEduc & Res BP, Sao Paulo, Brazil
dc.description.affiliationPIO XII Fdn, Hosp Canc Barretos, Dept Head & Neck Surg, Rua Antenor Duarte Villela 1-131, Barretos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biol Sci, Lab Canc Mol Biol, Diadema, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior - CAPES
dc.description.sponsorshipNational Counsel of Technological and Scientific Development - CNPq
dc.format.extent707-717
dc.identifierhttp://dx.doi.org/10.2174/1566524018666180322162145
dc.identifier.citationCurrent Molecular Medicine. Sharjah, v. 17, n. 10, p. 707-717, 2017.
dc.identifier.doi10.2174/1566524018666180322162145
dc.identifier.issn1566-5240
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55276
dc.identifier.wosWOS:000432350100005
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Molecular Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectHead and neck squamous cell carcinomaen
dc.subjectcancer/testis antigensen
dc.subjectmRNA expressionen
dc.subjectprognostic markersen
dc.subjectGAGE1en
dc.subjectXAGE1en
dc.titleExpression and Prognostic Relevance of GAGE1 and XAGE1 Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinomaen
dc.typeinfo:eu-repo/semantics/article
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