Autologous stem cell transplantation improves quality of life in economically challenged, Brazilian multiple myeloma patients

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dc.contributor.authorEtto, Leina Y [UNIFESP]
dc.contributor.authorMorel, Vânia Maris [UNIFESP]
dc.contributor.authorSilva, Vanderleia C [UNIFESP]
dc.contributor.authorHungria, Vania Tietsche de Moraes
dc.contributor.authorCiconelli, Rozana Mesquita [UNIFESP]
dc.contributor.authorAlmeida, Manuella S. S [UNIFESP]
dc.contributor.authorOliveira, José Salvador Rodrigues de [UNIFESP]
dc.contributor.authorBarros, José Carlos
dc.contributor.authorDurie, Brian G
dc.contributor.authorColleoni, Gisele Wally Braga [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionSanta Casa de Misericórdia de São Paulo Faculdade de Ciências Médicas
dc.contributor.institutionCedars-Sinai Outpatient Cancer Center
dc.date.accessioned2015-06-14T13:42:45Z
dc.date.available2015-06-14T13:42:45Z
dc.date.issued2011-01-01
dc.description.abstractOBJECTIVES: 1) To characterize the impact of multiple myeloma on the quality of life of patients treated in two public institutions in São Paulo State, Brazil, using a generic Short Form 36 Health Survey and a questionnaire specific for oncologic patients (QLQ-C30) upon diagnosis, after the clinical treatment, and at day +100 after autologous stem cell transplantation; 2) to evaluate whether autologous stem cell transplantation can improve the quality of life of our economically challenged population aside from providing a clinical benefit and disease control. METHODS: We evaluated 49 patients with multiple myeloma (a total of 70 interviews) using the two questionnaires. The scores upon diagnosis, post-treatment/pre-autologous stem cell transplantation, and at D+100 were compared using ANOVA (a comparison of the three groups), post hoc tests (two-by-two comparisons of the three groups), and paired t-tests (the same case at two different times). RESULTS: Of the included patients, 87.8% had a family budget under US $600 (economic class C, D, or E) per month. The generic Short Form 36 Health Survey questionnaire demonstrated that physical function, role-physical, and bodily pain indices were statistically different across all three groups, favoring the D+100 autologous stem cell transplantation group (ANOVA). The questionnaire specific for oncologic patients, the QLQ-C30 questionnaire, confirmed what had been demonstrated by the Short Form 36 Health Survey with respect to physical function and bodily pain, with improvements in role functioning, fatigue, and lack of appetite and constipation, favoring the D+100 autologous stem cell transplant group (ANOVA). The post hoc tests and paired t-tests confirmed a better outcome after autologous stem cell transplantation CONCLUSION: The questionnaire specific for cancer patients seems to be more informative than the generic Short Form 36 Health Survey questionnaire and reflects the real benefit of autologous stem cell transplantation in the quality of life of multiple myeloma patients in two public Brazilian institutions that provide assistance for economically challenged patients.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationSanta Casa de Misericórdia de São Paulo Faculdade de Ciências Médicas
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Medicina
dc.description.affiliationCedars-Sinai Outpatient Cancer Center
dc.description.affiliationUnifespUNIFESP, Depto. de Medicina
dc.description.sourceSciELO
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1855-1859
dc.identifierhttp://dx.doi.org/10.1590/S1807-59322011001100002
dc.identifier.citationClinics. Faculdade de Medicina / USP, v. 66, n. 11, p. 1855-1859, 2011.
dc.identifier.doi10.1590/S1807-59322011001100002
dc.identifier.fileS1807-59322011001100002.pdf
dc.identifier.issn1807-5932
dc.identifier.scieloS1807-59322011001100002
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/6161
dc.identifier.wosWOS:000297498600002
dc.language.isoeng
dc.publisherFaculdade de Medicina / USP
dc.relation.ispartofClinics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMyelomaen
dc.subjectQuality of lifeen
dc.subjectSF-36en
dc.subjectQLQ-C30en
dc.subjectTransplantationen
dc.titleAutologous stem cell transplantation improves quality of life in economically challenged, Brazilian multiple myeloma patientsen
dc.typeinfo:eu-repo/semantics/article
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