Psychopharmacology and psychotherapy for the treatment of adults with ADHD-a systematic review of available meta-analyses

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dc.contributor.authorMoriyama, Tais S. [UNIFESP]
dc.contributor.authorPolanczyk, Guilherme V.
dc.contributor.authorTerzi, Fernanda S.
dc.contributor.authorFaria, Kauy M.
dc.contributor.authorRohde, Luis A.
dc.contributor.institutionNatl Inst Dev Psychiat Children & Adolescents INC
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Fed Rio Grande do Sul
dc.date.accessioned2016-01-24T14:34:49Z
dc.date.available2016-01-24T14:34:49Z
dc.date.issued2013-12-01
dc.description.abstractObjective/Introduction Attention-deficit/hyperactivity disorder (ADHD) in adult life is a prevalent condition. We systematically reviewed the literature available by searching for meta-analyses assessing pharmacological and psychosocial interventions for adults with ADHD.Methods Using wide-ranging search terms, we retrieved 191 titles from the PubMed and Cochrane databases. Two independent evaluators judged all abstracts. Only meta-analyses about the treatment of adults with ADHD were included. Information from meta-analyses found was systematically extracted by 3 independent evaluators.Results Eight meta-analyses were identified. Results from those meta-analyses suggest that stimulants are effective in decreasing ADHD symptoms on a short-term basis with a medium to large effect size (ES). Short-acting stimulants might be superior to long-acting stimulants, but no data on difference in adherence are available for the comparison of these two types of formulation. Bupropion is superior to placebo but less effective than stimulants. No conclusions about the impact of psychosocial interventions can be drawn based on meta-analyses so far.Discussion the efficacy of stimulants in reducing ADHD symptoms for adults is well documented in meta-analyses, but there is a concerning lack of meta-analysis about other treatment interventions.Conclusion the available meta-analytic literature does not cover questions of essential clinical relevance for adults with ADHD.en
dc.description.affiliationNatl Inst Dev Psychiat Children & Adolescents INC, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Dept Psychiat, Div Child & Adolescent Psychiat, São Paulo, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Dept Psychiat, Porto Alegre, RS, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNovartis
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipJanssen-Cilag
dc.description.sponsorshipAbbott
dc.description.sponsorshipEli-Lilly
dc.description.sponsorshipShire
dc.format.extent296-306
dc.identifierhttp://dx.doi.org/10.1017/S109285291300031X
dc.identifier.citationCns Spectrums. New York: Cambridge Univ Press, v. 18, n. 6, p. 296-306, 2013.
dc.identifier.doi10.1017/S109285291300031X
dc.identifier.issn1092-8529
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37049
dc.identifier.wosWOS:000327777100003
dc.language.isoeng
dc.publisherCambridge Univ Press
dc.relation.ispartofCns Spectrums
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://journals.cambridge.org/action/displaySpecialPage?pageId=4676
dc.subjectADHDen
dc.subjectadultsen
dc.subjectinattentionen
dc.subjectstimulantsen
dc.subjecttreatmenten
dc.titlePsychopharmacology and psychotherapy for the treatment of adults with ADHD-a systematic review of available meta-analysesen
dc.typeinfo:eu-repo/semantics/article
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