Effect of bee venom (Apis mellifera) on the phagocytosis of peritoneal macrophages and on the rise of life expectancy of Ehrlich tumor-bearing mice

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dc.contributor.authorFeder, David [UNIFESP]
dc.contributor.authorAlves, Andre Neves
dc.contributor.authorBeltramo, Joao Roberto
dc.contributor.authorBeltramo, Luana Ap.
dc.contributor.authorCoriolano, Maria Gabriela P.
dc.contributor.authorPerazzo, Fábio Ferreira [UNIFESP]
dc.contributor.authorFonseca, Fernando Luiz Affonso [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:30:25Z
dc.date.available2018-06-15T17:30:25Z
dc.date.issued2011-01-01
dc.description.abstractBee venom contains a variety of peptides, including the melittin, the apamine, the adolapin and mast cell degranulation peptides. Studies have shown anti-inflammatory and antitumor actions of this venom. The purposes of this study were to evaluate the bee venom antitumor action in Ehrlich tumor-bearing mice and the phagocytosis of the peritoneal macrophages of mice treated with this venom. We did not observe any increase in the survival time of Ehrlich tumor-bearing mice treated with bee venom in the dose 0.7 and 1.0 mg/kg/day. However, we observed an increase in the macrophage phagocythosis treated with bee venom in the dose 0.7 to 1.0 mg/kg/day.In addition to the immunostimulant action, previous studies detected an apoptosis increase in the mice inoculated with experimental tumor and treated with bee venom. In the dose we used, we could observe only an increase in the macrophages phagocythosis. We have been considering the possibility of studying higher doses of the venom, pondering the benefits and the side effects, especially those to the central nervous system.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Ciencias Biol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Ciencias Exatas & Terra, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ciencias Biol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ciencias Exatas & Terra, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent509-514
dc.identifier.citationHealthmed. Sarajevo: Drunpp-sarajevo, v. 5, n. 3, p. 509-514, 2011.
dc.identifier.issn1840-2291
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43755
dc.identifier.wosWOS:000290567700006
dc.language.isoeng
dc.publisherDrunpp-sarajevo
dc.relation.ispartofHealthmed
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectbee venomen
dc.subjectEhrlich tumor and life expectancyen
dc.titleEffect of bee venom (Apis mellifera) on the phagocytosis of peritoneal macrophages and on the rise of life expectancy of Ehrlich tumor-bearing miceen
dc.typeinfo:eu-repo/semantics/article
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