Alkaloids from croton echinocarpus baill.: Anti-hiv potential

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dc.contributor.authorRavanelli, N.
dc.contributor.authorSantos, Kátia P.
dc.contributor.authorMotta, Lucimar Barbosa da
dc.contributor.authorLago, Joao Henrique Ghilardi [UNIFESP]
dc.contributor.authorFurlan, Cláudia Maria
dc.date.accessioned2019-01-21T10:30:14Z
dc.date.available2019-01-21T10:30:14Z
dc.date.issued2016
dc.description.abstractCroton belongs to the Euphorbiaceae genus, one of the major Angiosperms families, and is widely distributed throughout the world, especially in the tropics. In this study, the hydroalcoholic extract (70% EtOH) of Croton echinocarpus leaves afforded two alkaloids: corydine and norisoboldine, and their structures were established by spectroscopic data interpretation (UV, IR, NMR and LREIMS). Both alkaloids displayed significant in vitro anti-HIV potential, inhibiting 40% of the HIV-1 reverse transcriptase enzyme activity at a concentration of 100 mu g mL(-1) of norisoboldine and 450 mu g mL(-1) of corydine. Corydine showed IC50 of 356.8 mu g mL(-1), while norisoboldine was more efficient on inhibiting the RT activity, showing IC50 of 153.7 mu g mL(-1). (C) 2015 SAAB. Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationDepartment of Botany, Institute of Bioscience, University of São Paulo, Rua do Matão 277, CEP 05508-090 São Paulo, SP, Brazil
dc.description.affiliationUniversidade Paulista, Rua Apeninos 267, CEP 01533-000 São Paulo, SP, Brazil
dc.description.affiliationInstituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Rua Prof. Arthur Riedel 275, CEP 09972-270 Diadema, SP, Brazil
dc.description.affiliationUnifespInstituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Rua Prof. Arthur Riedel 275, CEP 09972-270 Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [FAPESP 2012/10079-0]
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipIDFAPESP: 2012/10079-0
dc.format.extent153-156
dc.identifierhttps://doi.org/10.1016/j.sajb.2015.06.011
dc.identifier.citationSouth African Journal Of Botany. Amsterdam, v. 102, p. 153-156, 2016.
dc.identifier.doi10.1016/j.sajb.2015.06.011
dc.identifier.issn0254-6299
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49647
dc.identifier.wosWOS:000368959100021
dc.language.isoeng
dc.publisherElsevier science bv
dc.relation.ispartofSouth African Journal Of Botany
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNorisoboldineen
dc.subjectCorydineen
dc.subjectCrotonen
dc.subjectAnti-Hiv ActivityDragons Blooden
dc.subjectMolecular Phylogeneticsen
dc.subjectEuphorbiaceaeen
dc.subjectExtractsen
dc.subjectIdentificationen
dc.subjectConstituentsen
dc.subjectUrucuranaen
dc.subjectPlantsen
dc.titleAlkaloids from croton echinocarpus baill.: Anti-hiv potentialen
dc.typeinfo:eu-repo/semantics/article
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