Lipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpis

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dc.citation.volume10
dc.contributor.authorNogueira, Paula M.
dc.contributor.authorGuimaraes, Agna C.
dc.contributor.authorAssis, Rafael R.
dc.contributor.authorSadlova, Jovana
dc.contributor.authorMyskova, Jitka
dc.contributor.authorPruzinova, Katerina
dc.contributor.authorHlavackova, Jana
dc.contributor.authorTurco, Salvatore J.
dc.contributor.authorTorrecilhas, Ana C. [UNIFESP]
dc.contributor.authorVolf, Petr
dc.contributor.authorSoares, Rodrigo P.
dc.coverageLondon
dc.date.accessioned2020-07-02T18:52:18Z
dc.date.available2020-07-02T18:52:18Z
dc.date.issued2017
dc.description.abstractBackground: Lipophosphoglycan (LPG) is a dominant surface molecule of Leishmania promastigotes. Its species-specific polymorphisms are found mainly in the sugars that branch off the conserved Gal(beta 1,4) Man(alpha 1)-PO4 backbone of repeat units. Leishmania amazonensis is one of the most important species causing human cutaneous leishmaniasis in the New World. Here, we describe LPG intraspecific polymorphisms in two Le. amazonensis reference strains and their role during the development in three sand fly species. Results: Strains isolated from Lutzomyia flaviscutellata (PH8) and from a human patient (Josefa) displayed structural polymorphism in the LPG repeat units, possessing side chains with 1 and 2 beta-glucose or 1 to 3 beta-galactose, respectively. Both strains successfully infected permissive vectors Lutzomyia longipalpis and Lutzomyia migonei and could colonize their stomodeal valve and differentiate into metacyclic forms. Despite bearing terminal galactose residues on LPG, Josefa could not sustain infection in the restrictive vector Phlebotomus papatasi. Conclusions: LPG polymorphisms did not affect the ability of Le. amazonensis to develop late-stage infections in permissive vectors. However, the non-establishment of infection in Ph. papatasi by Josefa strain suggested other LPG-independent factors in this restrictive vector.en
dc.description.affiliationFiocruz MS, Inst Rene Rachou, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Dept Parasitol, Belo Horizonte, MG, Brazil
dc.description.affiliationCharles Univ Prague, Fac Sci, Dept Parasitol, Prague, Czech Republic
dc.description.affiliationUniv Kentucky, Med Ctr, Dept Biochem, Lexington, KY 40536 USA
dc.description.affiliationUniv Fed Sao Paulo, Dept Farm, Lab Imunol Celular & Bioquim Fungos & Protozoario, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Farm, Lab Imunol Celular & Bioquim Fungos & Protozoario, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Pesquisa e Desenvolvimento [CNPq PAPES VI 407438/2012-2]
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Minas Gerais [PPM-00102-16]
dc.description.sponsorshipCharles University [UNCE 204017/2012]
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP 2016-01917-3]
dc.description.sponsorshipID[CNPq PAPES VI 407438/2012-2]
dc.description.sponsorshipIDFundacao de Amparo a Pesquisa do Estado de Minas Gerais [PPM-00102-16]
dc.description.sponsorshipIDFundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP 2016-01917-3]
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1186/s13071-017-2568-8
dc.identifier.citationParasites & Vectors. London, v. 10, p. -, 2017.
dc.identifier.doi10.1186/s13071-017-2568-8
dc.identifier.fileWOS000418044700001.pdf
dc.identifier.issn1756-3305
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53991
dc.identifier.wosWOS:000418044700001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofParasites & Vectors
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLeishmania amazonensisen
dc.subjectLipophosphoglycanen
dc.subjectLutzomyia longipalpisen
dc.subjectLutzomyia migoneien
dc.subjectPhlebotomus papatasien
dc.subjectVector-parasite interactionen
dc.titleLipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpisen
dc.typeinfo:eu-repo/semantics/article
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