Permanent global amnesia: case report

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dc.contributor.authorBertolucci, Paulo Henrique Ferreira [UNIFESP]
dc.contributor.authorSiviero, Marilena Occhini [UNIFESP]
dc.contributor.authorBueno, Orlando Francisco Amodeo [UNIFESP]
dc.contributor.authorOkamoto, Ivan Hideyo [UNIFESP]
dc.contributor.authorCamargo, CHP
dc.contributor.authorSantos, R. F.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T16:52:46Z
dc.date.available2018-06-15T16:52:46Z
dc.date.issued2004-04-01
dc.description.abstractPurpose: To present a case of permanent global amnesia related to hippocampal damage. Permanent global amnesia is a very rare condition of unknown etiology; lesions restricted to the hippocampus are uncommon, which hinders investigations of this pattern of memory loss. This case is unusually well documented, as the patient underwent extensive neuropsychological evaluations. Clinical features: A cheerful right-handed, 83-year-old retired electrician was first evaluated in 1990 for progressive difficulty in learning new information and in recalling events over the preceding 3-4 years. Tests over the next 5 years showed that the impairment was confined to episodic declarative memory. New verbal information could be stored only in episodic memory in a restricted manner, limited by short-term memory capacity. A relatively mild retrograde amnesia was detected. Semantic and implicit memory was spared, as were other functions evaluated. The patient's language and executive function were strikingly efficient. Magnetic resonance imaging of the brain showed bilateral atrophy of the hippocampi and amygdalae, ruling out conditions such as tumour growth. A diagnosis of permanent global amnesia was made. In the ensuing years, the retrograde amnesia worsened, but no new deficits were identified. Conclusion: This case, the first with a detailed cognitive examination, is evidence of a relatively pure hippocampal pattern for memory loss in permanent global amnesia.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Neurol & Neurosurg, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychiat, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Neurol & Neurosurg, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychobiol, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychiat, BR-04023900 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent101-106
dc.identifier.citationClinical And Investigative Medicine-medecine Clinique Et Experimentale. Ottawa: Canadian Medical Association, v. 27, n. 2, p. 101-106, 2004.
dc.identifier.issn0147-958X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43347
dc.identifier.wosWOS:000221785500007
dc.language.isoeng
dc.publisherCanadian Medical Association
dc.relation.ispartofClinical And Investigative Medicine-medecine Clinique Et Experimentale
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titlePermanent global amnesia: case reporten
dc.typeinfo:eu-repo/semantics/article
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