Study of ProtoPorphyrin IX Elimination by Body Excreta: A new Noninvasive Cancer Diagnostic Method?

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dc.contributor.authorSilva, Flavia R. O. [UNIFESP]
dc.contributor.authorNabeshima, Camila Tiemi [UNIFESP]
dc.contributor.authorBellini, Maria H. [UNIFESP]
dc.contributor.authorSchor, Nestor [UNIFESP]
dc.contributor.authorVieira, Nilson D.
dc.contributor.authorCourrol, Lilia C. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionIPEN CNEN SP
dc.date.accessioned2016-01-24T14:31:00Z
dc.date.available2016-01-24T14:31:00Z
dc.date.issued2013-01-01
dc.description.abstractThis paper describes the elimination of porphyrins by feces. It was demonstrated that porphyrin accumulates substantially more in tumors than in normal tissues, and consequently more PPIX reaches the blood of patients and animals with tumors, and then, it needs to be eliminated. the fluorescence of feces revealed that there are large amounts of PPIX in the excreta of animals with cancer comparing with healthy animals. the autofluorescence of feces porphyrin extracted with acetone was analyzed using fluorescence spectroscopy of animals inoculated with DU145 cells into the prostate and healthy animals to monitor the PPIX concentration. Emission spectra were obtained by exciting the samples at 405 nm. Significant differences were observed in autofluorescence intensities measured in the 575-725 nm spectral regions for the studied groups. the results showed a noninvasive, simple, rapid and sensitive method to detect cancer by feces analysis.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Nefrol, São Paulo, Brazil
dc.description.affiliationIPEN CNEN SP, Ctr Ciencia & Tecnol Mat, São Paulo, Brazil
dc.description.affiliationIPEN CNEN SP, Ctr Lasers & Aplicacoes, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Nefrol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent131-135
dc.identifierhttp://dx.doi.org/10.1007/s10895-012-1126-1
dc.identifier.citationJournal of Fluorescence. New York: Springer/plenum Publishers, v. 23, n. 1, p. 131-135, 2013.
dc.identifier.doi10.1007/s10895-012-1126-1
dc.identifier.issn1053-0509
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35785
dc.identifier.wosWOS:000314094000015
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal of Fluorescence
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectCanceren
dc.subjectFecesen
dc.subjectPorphyrinen
dc.subjectFluorescenceen
dc.subjectPhotodiagnosisen
dc.titleStudy of ProtoPorphyrin IX Elimination by Body Excreta: A new Noninvasive Cancer Diagnostic Method?en
dc.typeinfo:eu-repo/semantics/article
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