Genetic divergence of Toxoplasma gondii strains associated with ocular toxoplasmosis, Brazil

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dc.contributor.authorKhan, Asis
dc.contributor.authorJordan, Catherine
dc.contributor.authorMuccioli, Cristina [UNIFESP]
dc.contributor.authorVallochi, Adriana L.
dc.contributor.authorRizzo, Luiz V.
dc.contributor.authorBelfort, Rubens Junior [UNIFESP]
dc.contributor.authorVitor, Ricardo W. A.
dc.contributor.authorSilveira, Claudio [UNIFESP]
dc.contributor.authorSibley, L. David
dc.contributor.institutionWashington Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionClin Silveira
dc.date.accessioned2018-06-15T17:17:28Z
dc.date.available2018-06-15T17:17:28Z
dc.date.issued2006-06-01
dc.description.abstractPrevious studies have shown a high prevalence of toxoplasmosis and the frequent occurrence of ocular disease in Brazil. To identify the genotypes of parasite strains associated with ocular disease, we compared 25 clinical and animal isolates of Toxoplasma gondii from Brazil to previously characterized clonal lineages from North America and Europe. Multilocus nested polymerase chain reaction analysis was combined with direct sequencing of a polymorphic intron to classify strains by phylogenetic methods. The genotypes of T gondii strains isolated from Brazil were highly divergent when compared to the previously described clonal lineages. Several new predominant genotypes were identified from different regions of Brazil, including 2 small outbreaks attributable to foodborne or waterborne infection. These findings show that the genetic makeup of T gondii is more complex than previously recognized and suggest that unique or divergent genotypes may contribute to different clinical outcomes of toxoplasmosis in different localities.en
dc.description.affiliationWashington Univ, Sch Med, St Louis, MO 63130 USA
dc.description.affiliationEscola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, BR-05508 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Minas Gerais, BR-30000 Belo Horizonte, MG, Brazil
dc.description.affiliationClin Silveira, Erechim, Brazil
dc.description.affiliationUnifespEscola Paulista Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent942-949
dc.identifierhttps://wwwnc.cdc.gov/eid/article/12/6/06-0025_article
dc.identifier.citationEmerging Infectious Diseases. Atlanta: Center Disease Control, v. 12, n. 6, p. 942-949, 2006.
dc.identifier.doi10.3201/eid1206.060025
dc.identifier.issn1080-6040
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43523
dc.identifier.wosWOS:000237829900010
dc.language.isoeng
dc.publisherCenter Disease Control
dc.relation.ispartofEmerging Infectious Diseases
dc.rightsAcesso aberto
dc.titleGenetic divergence of Toxoplasma gondii strains associated with ocular toxoplasmosis, Brazilen
dc.typeArtigo
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