Uropathogenic Escherichia coli (UPEC) strains may carry virulence properties of diarrhoeagenic E-coli

Página do item simplificado
dc.contributor.authorAbe, Cecilia Mari [UNIFESP]
dc.contributor.authorSalvador, Fábia Andréia [UNIFESP]
dc.contributor.authorFalsetti, Ivan N. [UNIFESP]
dc.contributor.authorVieira, Monica A. M. [UNIFESP]
dc.contributor.authorBlanco, Jorge
dc.contributor.authorBlanco, Jesus E.
dc.contributor.authorBlanco, Miguel
dc.contributor.authorMachado, Antonia M. O. [UNIFESP]
dc.contributor.authorElias Junior, Waldir Pereira [UNIFESP]
dc.contributor.authorHernandes, Rodrigo T. [UNIFESP]
dc.contributor.authorGomes, Tania Aparecida Tardelli [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Santiago de Compostela
dc.contributor.institutionInst Butantan
dc.date.accessioned2016-01-24T13:49:40Z
dc.date.available2016-01-24T13:49:40Z
dc.date.issued2008-04-01
dc.description.abstractTo analyze whether Escherichia coli strains that cause urinary tract infections (UPEC) share virulence characteristics with the diarrheagenic E. coli (DEC) pathotypes and to recognize their genetic diversity, 225 UPEC strains were examined for the presence of various properties of DEC and UPEC (type of interaction with HeLa cells, serogroups and presence of 30 virulence genes). No correlation between adherence patterns and serogroups was observed. Forty-five serogroups were found, but 64% of the strains belonged to one of the 12 serogroups (O1, O2, O4, O6, O7, O14, O15, O18, O21, O25, O75, and O175) and carried UPEC virulence genes (pap, hly, aer, sfa, cnf). the DEC genes found were: aap, aatA, aggC, agg3C, aggR, astA, eae, ehly, iha, irp2, lpfA(O113), pet, pic, pilS, and shf. Sixteen strains presented aggregative adherence and/or the aatA sequence, which are characteristics of enteroaggregative E. coli (EAEC), one of the DEC pathotypes. in summary, certain UPEC strains may carry DEC virulence properties, mostly associated to the EAEC pathotype. This finding raises the possibility that at least some faecal EAEC strains might represent potential uropathogens. Alternatively, certain UPEC strains may have acquired EAEC properties, becoming a potential cause of diarrhoea.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Microbiol Immunol & Parasitol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv Santiago de Compostela, Fac Vet, Dept Microbiol & Parasitol, Lab Referencia E Coli, Lugo, Spain
dc.description.affiliationUniversidade Federal de São Paulo, Lab Cent Hosp São Paulo, São Paulo, Brazil
dc.description.affiliationInst Butantan, Bacteriol Lab, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Microbiol Immunol & Parasitol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Lab Cent Hosp São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent397-406
dc.identifierhttp://dx.doi.org/10.1111/j.1574-695X.2008.00388.x
dc.identifier.citationFems Immunology and Medical Microbiology. Oxford: Blackwell Publishing, v. 52, n. 3, p. 397-406, 2008.
dc.identifier.doi10.1111/j.1574-695X.2008.00388.x
dc.identifier.issn0928-8244
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30538
dc.identifier.wosWOS:000253978900011
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofFems Immunology and Medical Microbiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEscherichia colien
dc.subjecturopathogenic E. coli (UPEC)en
dc.subjectenteroaggregative E. coli (EAEC)en
dc.subjectvirulence factorsen
dc.subjectdiarrhoeagenic E. coli (DEC)en
dc.titleUropathogenic Escherichia coli (UPEC) strains may carry virulence properties of diarrhoeagenic E-colien
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos