Thrombocytemia as a predictor of portal hypertension in schistosomiasis

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dc.contributor.authorSouza, Marilia Rodrigues Freitas de [UNIFESP]
dc.contributor.authorToledo, Carlos Fischer de [UNIFESP]
dc.contributor.authorBorges, Durval Rosa [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:17:24Z
dc.date.available2018-06-15T17:17:24Z
dc.date.issued2000-10-01
dc.description.abstractSufferers of schistosomiasis mansoni can evolve a clinical form of the disease associated with portal hypertension. To differentiate this form, routine clinical tests and biological indices were evaluated. In all, 54 HBsAg- and HCV-negative patients were studied, 42 with schistosomiasis and 12 normal volunteers. Using clinical criteria, ultrasonography, and endoscopy, the schistosomiasis patients were classified into two groups: mild chronic form (MS, N = 14) and chronic form associated with portal hypertension (PH, N = 28). The laboratory parameters of the MS group did not differ from the controls. The PH group differed from the others in prothrombin index, thrombocytemia, gamma -glutamyltransferase, serum alpha (2)-macroglobulin, and the calculated indices. ROC plot cutoff levels verified that isolated thrombocytemia was the most efficient marker for discrimination of the PH and MS forms. Thrombocytemia of 130 x 10(9) platelets/liter discriminated the groups with an 86% accuracy when all patients were analyzed and 96% when only schistosomiasis patients who did not consume alcohol were included.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Med, Div Gastroenterol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Med, Div Gastroenterol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1964-1970
dc.identifierhttp://dx.doi.org/10.1023/A:1005535808464
dc.identifier.citationDigestive Diseases And Sciences. Dordrecht: Springer, v. 45, n. 10, p. 1964-1970, 2000.
dc.identifier.doi10.1023/A:1005535808464
dc.identifier.issn0163-2116
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43492
dc.identifier.wosWOS:000165435500011
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofDigestive Diseases And Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectplateletsen
dc.subjectschistosomiasisen
dc.subjectportal hypertensionen
dc.subjecthypersplenismen
dc.titleThrombocytemia as a predictor of portal hypertension in schistosomiasisen
dc.typeinfo:eu-repo/semantics/article
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