Comparative study of the growth and nutritional status of Brazilian and Nigerian school-aged children with sickle cell disease

dc.citation.issue6
dc.citation.volume9
dc.contributor.authorAdegoke, Samuel A. [UNIFESP]
dc.contributor.authorFigueiredo, Maria S. [UNIFESP]
dc.contributor.authorAdekile, Adekunle D.
dc.contributor.authorBraga, Josefina A. P. [UNIFESP]
dc.coverageOxford
dc.date.accessioned2020-09-01T13:21:20Z
dc.date.available2020-09-01T13:21:20Z
dc.date.issued2017
dc.description.abstractBackground: Comparative studies of patients in different sociogeographic/ecological zones may unravel potential environmental and nutritional factors influencing disease phenotype. In sickle cell disease (SCD), differential access to comprehensive care may influence their growth and nutritional status. Methods: From June 2015 to February 2016, steady-state nutritional parameters of 109 Brazilian and 95 Nigerian children with SCD attending routine clinic visits at Universidade Federal de Sao Paulo, Brazil and Obafemi Awolowo University Teaching Hospital, Ile-Ife (Ilesa unit), respectively, were compared. Results: A relatively high proportion of the children in both centres (23.5%) were wasted [body-mass index (BMI)-for-age z-score<-2). BMI-for-age z-score, height-for-age z-score, upper arm fat area and fat percentage were lower in the Nigerian cohorts. More Nigerians, 29.5% (28/95) against 18.3% (20/109) were wasted, and had short stature, [12.6% (12/95) vs. 3.7% (4/109)] than Brazilians. A higher proportion of Brazilian patients were overweight or obese (9.2 vs. 4.3%), and taller for age (15.6 vs. 8.4%). None of the Nigerian patients had severe vitamin D deficiency, only 12.6% (12/95) had suboptimal vitamin D and 1.1% (1/95) had low serum zinc levels, unlike 79.8% (87/109) of the Brazilian patients with suboptimal vitamin D and 10.1% (11/109) with low zinc. Conclusion: Undernutrition is still prevalent among the two cohorts. Nigerian patients were thinner and had reduced linear growth for age. This observation justifies the continued need for specialized nutritional care for children with SCD. In addition to hydroxyurea therapy, research is needed to determine appropriate nutritional intervention and exercise regimens for these children.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Haematol & Blood Transfus Div, Sao Paulo, Brazil
dc.description.affiliationObafemi Awolowo Univ, Dept Pediat & Child Hlth, Ife, Nigeria
dc.description.affiliationKuwait Univ, Fac Med, Dept Paediat, Kuwait, Kuwait
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Pediat, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Haematol & Blood Transfus Div, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Pediat, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCNPq
dc.description.sponsorshipIDCNPq: 159581/2014-1
dc.format.extent327-334
dc.identifierhttp://dx.doi.org/10.1093/inthealth/ihx035
dc.identifier.citationInternational Health. Oxford, v. 9, n. 6, p. 327-334, 2017.
dc.identifier.doi10.1093/inthealth/ihx035
dc.identifier.fileWOS000419582000002.pdf
dc.identifier.issn1876-3413
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58203
dc.identifier.wosWOS:000419582000002
dc.language.isoeng
dc.publisherOxford Univ Press
dc.relation.ispartofInternational Health
dc.rightsAcesso aberto
dc.subjectBrazilianen
dc.subjectChildrenen
dc.subjectGrowthen
dc.subjectNigerianen
dc.subjectNutritional statusen
dc.subjectSickle cell diseaseen
dc.titleComparative study of the growth and nutritional status of Brazilian and Nigerian school-aged children with sickle cell diseaseen
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