Left Atrial Dysfunction in Chagas Cardiomyopathy Is More Severe Than in Idiopathic Dilated Cardiomyopathy: A Study with Real-Time Three-Dimensional Echocardiography

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dc.contributor.authorMancuso, Frederico José Neves [UNIFESP]
dc.contributor.authorAlmeida, Dirceu Rodrigues de [UNIFESP]
dc.contributor.authorMoisés, Valdir Ambrósio [UNIFESP]
dc.contributor.authorOliveira, Wercules Antonio [UNIFESP]
dc.contributor.authorMello, Eduardo S. [UNIFESP]
dc.contributor.authorPoyares, Dalva [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorCarvalho, Antonio Carlos [UNIFESP]
dc.contributor.authorCampos, Orlando [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:06:26Z
dc.date.available2016-01-24T14:06:26Z
dc.date.issued2011-05-01
dc.description.abstractBackground: Although there is anatomopathologic evidence of atrial involvement in Chagas cardiomyopathy (CCM), the impact in left atrial (LA) function is unknown. the aim of this study was to evaluate LA function in patients with CCM with real-time three-dimensional echocardiography (RT3DE) and to compare it with patients with idiopathic dilated cardiomyopathy (DCM).Methods: A total of 30 patients with CCM, 30 patients with DCM, and 20 normal subjects used as the control group were studied. With the use of RT3DE, we measured LA maximum (maxLAV), minimum, and pre-atrial contraction volumes and calculated total and active LA emptying fractions.Results: Left ventricular ejection fraction and mitral regurgitation were similar in both groups. MaxLAV/m(2) was larger in the CCM group than in the DCM group (76.9 +/- 21.9 mL vs. 59.1 +/- 26.0 mL; P < .01), and both were significantly larger than in the control group (P < .01). Total LA emptying fraction was lower in the CCM group than in the DCM group (0.30 +/- 0.10 vs. 0.40 +/- 0.12; P < .01), and both were lower than in the control group (P = .01). Active LA emptying fraction was also lower in the CCM group than in the DCM group (0.22 +/- 0.09 vs. 0.28 +/- 0.11; P < .01), and both were lower than in the control group (P = .01). the E/e' ratio was higher in the CCM group than in the DCM group (21 +/- 10 vs. 15 +/- 6; P < .01), and both were greater than in the control group (P < .01). in a multiple regression model, the E/e' ratio was the only independent predictor of a worsening active LA emptying fraction.Conclusion: LA function is more compromised in patients with CCM than in patients with DCM. This finding indicates a more diffuse and severe myocardial impairment in Chagas disease that is probably related to increased left ventricular filling pressures and atrial myopathy. (J Am Soc Echocardiogr 2011;24:526-32.)en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Internal Med, Discipline Cardiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Discipline Sleep Biol & Med, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Internal Med, Discipline Cardiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Discipline Sleep Biol & Med, Dept Psychobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent526-532
dc.identifierhttps://dx.doi.org/10.1016/j.echo.2011.01.013
dc.identifier.citationJournal of the American Society of Echocardiography. New York: Mosby-Elsevier, v. 24, n. 5, p. 526-532, 2011.
dc.identifier.doi10.1016/j.echo.2011.01.013
dc.identifier.issn0894-7317
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/33647
dc.identifier.wosWOS:000289779500008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of the American Society of Echocardiography
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectCardiomyopathyen
dc.subjectChagas diseaseen
dc.subjectLeft atriumen
dc.subjectReal-time three-dimensional echocardiographyen
dc.titleLeft Atrial Dysfunction in Chagas Cardiomyopathy Is More Severe Than in Idiopathic Dilated Cardiomyopathy: A Study with Real-Time Three-Dimensional Echocardiographyen
dc.typeinfo:eu-repo/semantics/article
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