Binary and ternary inclusion complexes of dapsone in cyclodextrins and polymers: preparation, characterization and evaluation

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dc.contributor.authorGrebogi, Ivanna H.
dc.contributor.authorTibola, Ana Paula O. V.
dc.contributor.authorBarison, Andersson
dc.contributor.authorGrandizoli, Caroline W. P. S.
dc.contributor.authorFerraz, Humberto G.
dc.contributor.authorRodrigues, Leticia N. C. [UNIFESP]
dc.contributor.institutionUniv Fed Parana
dc.contributor.institutionUniversidade Federal do Paraná (UFPR)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:27:30Z
dc.date.available2016-01-24T14:27:30Z
dc.date.issued2012-08-01
dc.description.abstractDapsone (DAP) is a synthetic sulfone drug with bacteriostatic activity, mainly against Mycobacterium leprae. in this study we have investigated the interactions of DAP with cyclodextrins, 2-hydroxypropyl-beta-cyclodextrin (HP beta CD) and beta-cyclodextrin (beta CD), in the presence and absence of water-soluble polymers, in order to improve its solubility and bioavailability. Solid systems DAP/HP beta CD and DAP/beta CD, in the presence or absence of polyvinylpyrrolidone (PVP K30) or hydroxypropyl methylcellulose (HPMC), were prepared. the binary and ternary systems were evaluated and characterized by SEM, DSC, XRD and NMR analysis as well as phase solubility assays, in order to investigate the interactions between DAP and the excipients in aqueous solution. This study revealed that inclusion complexes of DAP and cyclodextrins (HP beta CD and beta CD) can be produced in order to improve DAP solubility and bioavailability in the presence or absence of polymers (PVP K30 and HPMC). the more stable inclusion complex was obtained with HP beta CD, and consequently HP beta CD was more efficient in improving DAP solubility than beta CD, and the addition of polymers had no influence on DAP solubility or on the stability of the DAP/CDs complexes.en
dc.description.affiliationUniv Fed Parana, Lab Ressonancia Magnet Nucl, Dept Quim, Ctr Politecn, BR-81530000 Curitiba, Parana, Brazil
dc.description.affiliationUniv Fed Parana UFPR, Dept Farm, BR-80210170 Curitiba, Parana, Brazil
dc.description.affiliationUniv São Paulo, Fac Ciencias Farmaceut, BR-05508000 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent467-474
dc.identifierhttp://dx.doi.org/10.1007/s10847-011-0034-3
dc.identifier.citationJournal of Inclusion Phenomena and Macrocyclic Chemistry. Dordrecht: Springer, v. 73, n. 1-4, p. 467-474, 2012.
dc.identifier.doi10.1007/s10847-011-0034-3
dc.identifier.issn0923-0750
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35125
dc.identifier.wosWOS:000305232300051
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal of Inclusion Phenomena and Macrocyclic Chemistry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectDapsoneen
dc.subjectCyclodextrinen
dc.subjectInclusion complexen
dc.subjectHP beta CDen
dc.subjectbeta CDen
dc.titleBinary and ternary inclusion complexes of dapsone in cyclodextrins and polymers: preparation, characterization and evaluationen
dc.typeinfo:eu-repo/semantics/article
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