Lifetime psychopathology among the offspring of Bipolar I parents

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dc.contributor.authorZappitelli, Marcelo Cardoso [UNIFESP]
dc.contributor.authorBordin, Isabel Altenfelder Santos [UNIFESP]
dc.contributor.authorHatch, John P.
dc.contributor.authorCaetano, Sheila Cavalcante [UNIFESP]
dc.contributor.authorZunta-Soares, Giovana
dc.contributor.authorOlvera, Rene L.
dc.contributor.authorSoares, Jair C.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionThe University of Texas Health Science Center Departments of Psychiatry and Orthodontics
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversity of Texas Health Science Center
dc.contributor.institutionThe University of Texas Health Science Center Department of Psychiatry
dc.date.accessioned2015-06-14T13:42:52Z
dc.date.available2015-06-14T13:42:52Z
dc.date.issued2011-01-01
dc.description.abstractBACKGROUND: Recent studies have demonstrated high rates of psychopathology in the offspring of parents with bipolar disorder. The aim of this study was to identify psychiatric diagnoses in a sample of children of bipolar parents. METHOD: This case series comprised 35 children and adolescents aged 6 to 17 years, with a mean age of 12.5 + 2.9 years (20 males and 15 females), who had at least one parent with bipolar disorder type I. The subjects were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime version (K-SADS-PL). Family psychiatric history and demographics were also evaluated. RESULTS: Of the offspring studied, 71.4% had a lifetime diagnosis of at least one psychiatric disorder (28.6% with a mood disorder, 40% with a disruptive behavior disorder and 20% with an anxiety disorder). Pure mood disorders (11.4%) occurred less frequently than mood disorders comorbid with attention deficit hyperactivity disorder (17.1%). Psychopathology was commonly reported in second-degree relatives of the offspring of parents with bipolar disorder (71.4%). CONCLUSIONS: Our results support previous findings of an increased risk for developing psychopathology, predominantly mood and disruptive disorders, in the offspring of bipolar individuals. Prospective studies with larger samples are needed to confirm and expand these results.en
dc.description.affiliationFederal University of São Paulo Department of Psychiatry
dc.description.affiliationThe University of Texas Health Science Center Departments of Psychiatry and Orthodontics
dc.description.affiliationUniversidade de São Paulo Faculdade de Medicina Department of Psychiatry
dc.description.affiliationUniversity of Texas Health Science Center
dc.description.affiliationThe University of Texas Health Science Center Department of Psychiatry
dc.description.affiliationUnifespUNIFESP, Department of Psychiatry
dc.description.sourceSciELO
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipNARSAD
dc.description.sponsorshipKrus Endowed Chair in Psychiatry UTHSCSA
dc.description.sponsorshipIDNARSAD: MH 69774
dc.description.sponsorshipIDNARSAD: RR 20571
dc.description.sponsorshipIDNARSAD: MH068280
dc.format.extent725-730
dc.identifierhttp://dx.doi.org/10.1590/S1807-59322011000500003
dc.identifier.citationClinics. Faculdade de Medicina / USP, v. 66, n. 5, p. 725-730, 2011.
dc.identifier.doi10.1590/S1807-59322011000500003
dc.identifier.fileS1807-59322011000500003.pdf
dc.identifier.issn1807-5932
dc.identifier.scieloS1807-59322011000500003
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/6263
dc.identifier.wosWOS:000293122900003
dc.identifier.wos
dc.language.isoeng
dc.publisherFaculdade de Medicina / USP
dc.relation.ispartofClinics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBipolar Disorderen
dc.subjectOffspringen
dc.subjectPsychopathologyen
dc.subjectChilden
dc.subjectAdolescenten
dc.titleLifetime psychopathology among the offspring of Bipolar I parentsen
dc.typeinfo:eu-repo/semantics/article
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