Evaluation of the biological effects of 5-Cl-8-oxyquinolinepropoxycalix[4]arene and 8-oxyquinolinepropoxycalix[4]arene in vitro and in vivo

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dc.contributor.authorSoares, Marcos N. [UNIFESP]
dc.contributor.authorGascon, Thais M.
dc.contributor.authorFonseca, Fernando L. A. [UNIFESP]
dc.contributor.authorFerreira, Karen S. [UNIFESP]
dc.contributor.authorBagatin, Izilda A. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFundacao ABC
dc.date.accessioned2016-01-24T14:37:32Z
dc.date.available2016-01-24T14:37:32Z
dc.date.issued2014-07-01
dc.description.abstractThe development of antibacterial and antifungal drugs has been the target of several pharmaceutical and chemical industries mainly due to the lack of effective drugs with low or no side effect. in this work, studies were conducted both in vitro and in vivo with 8-oxyquinolinepropoxycalix[4]arene (A) and 5-Cl-8-oxyquinolinepropoxycalix[4]arene (B) ligands, showing fairly good results. Cytotoxicity and fungicidal actions of compounds A and B were determined in Wistar male rats and peritoneal macrophages of mice. A slight change in the total of leukocytes and erythrocytes was observed on the hematologic assays, showing almost no inflammation after using both compounds in Wistar male rats. We have also noted some, but not significant, alteration in liver enzymes representing modest hepatotoxicity. Cytotoxicity of peritoneal macrophages, in the presence of compound A or B, showed 50% of survival of macrophages. On the other hand, macrophages previously infected with Candida albicans and treated with substance A or B exhibited an increased cytokine IL-10 at 24 h incubation. By checking the effect of substance A or B on growing C. albicans, the results pointed that these substances revealed antifungal activity against C. albicans, in 24 h culture with a reduction of yeast cells. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP, Brazil
dc.description.affiliationFundacao ABC, Fac Med, BR-09060650 Santo Andre, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent260-266
dc.identifierhttp://dx.doi.org/10.1016/j.msec.2014.04.002
dc.identifier.citationMaterials Science & Engineering C-materials for Biological Applications. Amsterdam: Elsevier B.V., v. 40, p. 260-266, 2014.
dc.identifier.doi10.1016/j.msec.2014.04.002
dc.identifier.issn0928-4931
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37946
dc.identifier.wosWOS:000338388400035
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofMaterials Science & Engineering C-materials for Biological Applications
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectCalix[4]areneen
dc.subject8-Hydroxiquinolineen
dc.subjectFungicidal activityen
dc.subjectCytotoxicity effecten
dc.subjectIron depletionen
dc.titleEvaluation of the biological effects of 5-Cl-8-oxyquinolinepropoxycalix[4]arene and 8-oxyquinolinepropoxycalix[4]arene in vitro and in vivoen
dc.typeinfo:eu-repo/semantics/article
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