Obstructive Sleep Apnea Syndrome in the São Paulo Epidemiologic Sleep Study

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dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorSantos-Silva, Rogerio [UNIFESP]
dc.contributor.authorTaddei, Jose Augusto [UNIFESP]
dc.contributor.authorAzeredo Bittencourt, Lia Rita [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:59:39Z
dc.date.available2016-01-24T13:59:39Z
dc.date.issued2010-05-01
dc.description.abstractObjective: To estimate the prevalence of Obstructive Sleep Apnea Syndrome (OSAS), using current clinical and epidemiological techniques, among the adult population of São Paulo, Brazil.Methods: This population-based survey used a probabilistic three-stage cluster sample of São Paulo inhabitant S to represent the population according to gender, age (20-80 years), and socio-economic status. Face-to-face interviews and in-lab full-night polysomnographies using a nasal cannula were performed. the prevalence of OSAS was determined according to the criteria of the most recent International Classification of Sleep Disorders (ICDS-2) from American Academy of Sleep Medicine (2005).Results: A total of 1042 volunteers underwent polysomnography (refusal rate = 5.4%). the mean age +/- SD was 42 +/- 14 years; 55% were women and 60% had a body mass index > 25 kg/m(2). OSAS was observed in 32.8% of the participants (95% CI, 29.6-36.3). A multivariate logistic regression model identified several independent and strong associations for the presence of OSAS: men had greater association than women (OR = 4.1; 95% Cl, 2.9-5.8; P < 0.001) and obese individuals (OR = 10.5; 95% Cl, 7.1-15.7; P < 0.001) than individuals of normal weight. the adjusted association factor increased with age, reaching OR = 34.5 (95% Cl. 18.5-64.2: P < 0.001) for 60-80 year olds when compared to the 20-29 year old group. Low socio-economic status was a protective factor for men (OR = 0.4), but was an associated factor for women (OR = 2.4). Self-reported menopause explained this increased association (age adjusted OR = 2.1; 95% Cl, 1.4-3.9; P < 0.001), and it was more frequent in the lowest class (43.1%) than either middle class (26.1%) or upper class (27.8%) women.Conclusions: This study is the first apnea survey of a large metropolitan area in South America identifying a higher prevalence of OSAS than found in other epidemiological studies. This can be explained by the use of the probabilistic sampling process achieving a very low polysomnography refusal rate, the use of current techniques and clinical criteria, inclusion of older groups, and the higher prevalence of obesity in the studied population. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, Disciplina Med & Biol Sono, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pediat, Disciplina Nutr & Metab, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, Disciplina Med & Biol Sono, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pediat, Disciplina Nutr & Metab, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Psicofarmacologia (AFIP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 07/50525-1
dc.description.sponsorshipIDFAPESP: 98/14303-3
dc.format.extent441-446
dc.identifierhttp://dx.doi.org/10.1016/j.sleep.2009.10.005
dc.identifier.citationSleep Medicine. Amsterdam: Elsevier B.V., v. 11, n. 5, p. 441-446, 2010.
dc.identifier.doi10.1016/j.sleep.2009.10.005
dc.identifier.issn1389-9457
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32518
dc.identifier.wosWOS:000277878500003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofSleep Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectObstructive Sleep Apnea Syndromeen
dc.subjectNasal cannulaen
dc.subjectEpidemiologyen
dc.subjectPolysomnographyen
dc.subjectPrevalenceen
dc.subjectPopulationen
dc.titleObstructive Sleep Apnea Syndrome in the São Paulo Epidemiologic Sleep Studyen
dc.typeinfo:eu-repo/semantics/article
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