The burden of premature mortality of epilepsy in high-income countries: A systematic review from the Mortality Task Force of the International League Against Epilepsy

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dc.citation.issue1
dc.citation.volume58
dc.contributor.authorThurman, David J.
dc.contributor.authorLogroscino, Giancarlo
dc.contributor.authorBeghi, Ettore
dc.contributor.authorHauser, W. Allen
dc.contributor.authorHesdorffer, Dale C.
dc.contributor.authorNewton, Charles R.
dc.contributor.authorScorza, Fulvio Alexandre [UNIFESP]
dc.contributor.authorSander, Josemir W.
dc.contributor.authorTomson, Torbjorn
dc.coverageHoboken
dc.date.accessioned2020-07-31T12:46:54Z
dc.date.available2020-07-31T12:46:54Z
dc.date.issued2017
dc.description.abstractSince previous reviews of epidemiologic studies of premature mortality among people with epilepsy were completed several years ago, a large body of new evidence about this subject has been published. We aim to update prior reviews of mortality in epilepsy and to reevaluate and quantify the risks, potential risk factors, and causes of these deaths. We systematically searched the Medline and Embase databases to identify published reports describing mortality risks in cohorts and populations of people with epilepsy. We reviewed relevant reports and applied criteria to identify those studies likely to accurately quantify these risks in representative populations. From these we extracted and summarized the reported data. All population-based studies reported an increased risk of premature mortality among people with epilepsy compared to general populations. Standard mortality ratios are especially high among people with epilepsy aged <50 years, among those whose epilepsy is categorized as structural/metabolic, those whose seizures do not fully remit under treatment, and those with convulsive seizures. Among deaths directly attributable to epilepsy or seizures, important immediate causes include sudden unexpected death in epilepsy (SUDEP), status epilepticus, unintentional injuries, and suicide. Epilepsy-associated premature mortality imposes a significant public health burden, and many of the specific causes of death are potentially preventable. These require increased attention from healthcare providers, researchers, and public health professionals.en
dc.description.affiliationEmory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA
dc.description.affiliationUniv Bari Aldo Moro, Pia Fdn Cardinale G Panico, Dept Clin Res Neurol, Lecce, Italy
dc.description.affiliationUniv Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy
dc.description.affiliationMario Negri Inst Pharmacol Res, Milan, Italy
dc.description.affiliationColumbia Univ, Sergievsky Ctr, New York, NY USA
dc.description.affiliationColumbia Univ, Mailman Sch Publ Hlth, New York, NY USA
dc.description.affiliationUCL, Inst Child Hlth, Dept Neurosci, London, England
dc.description.affiliationMuhimbili Univ Hlth & Allied Sci, Dept Paediat, Dar Es Salaam, Tanzania
dc.description.affiliationUniv Oxford, Dept Psychiat, Oxford, England
dc.description.affiliationUniv Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo, Brazil
dc.description.affiliationUCL Inst Neurol, NIHR Univ Coll London Hosp, Biomed Res Ctr, London, England
dc.description.affiliationEpilepsy Inst Netherlands Fdn SEIN, Heemstede, England
dc.description.affiliationKarolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
dc.description.affiliationUnifespDepartment of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipUpsherSmith
dc.description.sponsorshipCyberonics
dc.description.sponsorshipDepartment of Rehabilitation
dc.description.sponsorshipMount Sinai Medical Center
dc.description.sponsorshipNew York University Langone Comprehensive Epilepsy Center
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipCenters for Disease Control and Prevention
dc.description.sponsorshipEpilepsy Study Consortium
dc.description.sponsorshipEpilepsia
dc.description.sponsorshipWellcome Trust, United Kingdom
dc.description.sponsorshipDepartment of Health's NIHR Biomedical Research Centres
dc.description.sponsorshipMarvin Weil Epilepsy Research Fund
dc.description.sponsorshipGlaxoSmithKline (GSK)
dc.description.sponsorshipEisai
dc.description.sponsorshipUCB
dc.description.sponsorshipEuropean Union
dc.description.sponsorshipDutch Epilepsy Funds
dc.description.sponsorshipWorld Health Organization (WHO)
dc.description.sponsorshipUnited Kingdom Epilepsy Society
dc.description.sponsorshipGlaxoSmithKline
dc.description.sponsorshipNovartis
dc.description.sponsorshipBial
dc.description.sponsorshipCitizens United for Research in Epilepsy (CURE)
dc.description.sponsorshipStockholm County Council
dc.format.extent17-26
dc.identifierhttp://dx.doi.org/10.1111/epi.13604
dc.identifier.citationEpilepsia. Hoboken, v. 58, n. 1, p. 17-26, 2017.
dc.identifier.doi10.1111/epi.13604
dc.identifier.issn0013-9580
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56449
dc.identifier.wosWOS:000393682700005
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofEpilepsia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSeizuresen
dc.subjectConvulsionsen
dc.subjectDeathen
dc.subjectDeveloped countriesen
dc.subjectResource-rich countriesen
dc.subjectPremature mortalityen
dc.titleThe burden of premature mortality of epilepsy in high-income countries: A systematic review from the Mortality Task Force of the International League Against Epilepsyen
dc.typeinfo:eu-repo/semantics/article
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